Victor E. Marquez, Ph.D.

Victor E. Marquez, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Chemical Biology Laboratory


Dr. Marquez's main research interests centered on nucleoside chemistry and synthetic organic chemistry as tools for the rational design of antitumor and antiviral agents. One of the principal goals of his research was understanding the geometry of bioequivalent pharmacophores-present in diacylglycerol (DAG) and in the more potent phorbol esters that appeared to be responsible for binding to the regulatory C1 domains of protein kinase C (PKC) and other target proteins. These domains, which act as a molecular hydrophobic switch, represent regulatory modules in several families of proteins involved in signal transduction, including the PKC, chimaerin, and RasGRP families.  His laboratory also described the first synthesis of a conformationally locked bicyclo[3.1.0]hexane nucleoside.

Areas of Expertise

Nucleoside Chemistry
Synthetic Organic Chemistry