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Surajit Sinha, Ph.D.

Surajit Sinha, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Surgical Oncology Program

RESEARCH SUMMARY

Dr. Sinha is interested in the global reprogramming events, both at the molecular and proteomic levels, that drive tumor cell dissemination, dormancy and metastatic outgrowth.

Areas of Expertise

Biotechnology
Bioinformatics

Publications

Selected Publications

Multi-organ Site Metastatic Reactivation Mediated by Non-canonical Discoidin Domain Receptor 1 Signaling

Hua Gao, Goutam Chakraborty, Zhanguo Zhang, Intissar Akalay, Mayur Gadiya, Yaquan Gao, Surajit Sinha, Jian Hu, Cizhong Jiang, Muzaffar Akram, Edi Brogi, Birit Leitinger, and Gilippo G. Giancotti
Cell. 166: 47-62, 2016. [ Journal Article ]

The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling

Tomoyo Okada, Surajit Sinha, Ilaria Esposito, Gaia Schiavon, Miguel Lopez-Lago, Wenjing Su, Christine A. Pratilas, Cristina Abele, Jonathan Hernandez, Masahiro Ohara, Morihito Okada, Agnes Viale, Nick Socci, Anna Sapino, Venkatraman E. Seshan, Stephen Long, Giorgio Inghirami, Neal Rosen, and Filippo G. Giancotti
Nat Cell Biol. 17(1): 81-94, 2015. [ Journal Article ]

Coordinated regulation of p53 apoptotic targets BAX and PUMA by SMAR1 through an identical MAR element

Sinha S, Malonia SK, Mittal SP, Singh K, Kadreppa S, Kamat R, Mukhopadhyaya R, Pal JK, Chattopadhyay S
EMBO J. 29(4): 830-842, 2010. [ Journal Article ]

Chromatin remodeling protein SMAR1 regulates NF-κB dependent Interleukin-8 transcription in breast cancer

Malonia SK, Yadav B, Sinha S, Lazennec G, Chattopadhyay S.
Int J Biochem Cell Biol. 55: 220-226, 2014. [ Journal Article ]

Chromatin remodelling protein SMAR1 inhibits p53 dependent transactivation by regulating acetyl transferase p300

Sinha S, Malonia SK, Mittal SP, Mathai J, Pal JK, Chattopadhyay S.
Int J Biochem Cell Biol. 44(1): 46-52, 2012. [ Journal Article ]