Dr. Sinha’s interest is in global reprogramming events both at molecular and proteomic levels that drive tumor cell dissemination, dormancy and metastatic outgrowth. Dr. Sinha utilizes bioinformatic approaches and the lab’s gain-or-loss of function genetic screens to identify genes and upstream signaling events that dictate dormancy and metastatic reactivation of disseminated tumor cells. The long-term goal is to understand molecular and proteomic programs that dictate tumor cell phenotype, and develop targeted therapies that can induce perpetual dormancy in metastasis-initiating-cells (MICs).