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Sung Hyeok Hong, DVM, Ph.D.

Sung Hyeok Hong, DVM, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Sung Hyeok Hong is a veterinary surgeon and an independent scientist. In the Mackem lab, he manages transgenic mouse models for mouse limb development. Before joining Mackem lab, he developed an in vivo orthotopic metastasis model for studying colorectal cancer, neuroblastoma, prostate cancer, pancreatic cancer, breast cancer, Ewing sarcoma and osteosarcoma using surgical techniques. In addition, he established in vivo orthotopic brain tumor models, glioblastoma and medulloblastoma to discover new noble compound treatments.

Areas of Expertise

1) Transgenic Mouse Model  2) In Vivo Orthotopic Xenograft Model  3) Metastasis  4) Orthopedic and General Surgery  5) PK Modeling  6) Reading X-ray, CT and MRI

Publications

Selected Key Publications

Hypoxia-activated neuropeptide Y/Y5 receptor/RhoA pathway triggers chromosomal instability and bone metastasis in Ewing sarcoma

Lu C, Mahajan A, Hong SH, Galli S, Zhu S, Tilan JU, Abualsaud N, Adnani M, Chung S, Elmansy N, Rodgers J, Rodriguez O, Albanese C, Wang H, Regan M, Zgonc V, Blancato J, Krawczyk E, Gallicano GI, Girgis M, Cheema A, Iżycka-Świeszewska E, Cavalli LR, Pack SD, and Kitlinska J
Nature Communications. 13: 2323: 2022.
Full-Text Article
[ Journal Article ]

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

Hong SH, Tilan JU, Galli S, Acree R, Connors K, Mahajan A, Wietlisbach L, Polk T, Izycka-Swieszewska E, Lee Y-C, Cavalli LR, Rodriguez OC, Albanese C and Kitlinska JB
Journal of Visualized Experiments. 118:54532: 2016.
Full-Text Article
[ Journal Article ]

CCR5 deficiency normalizes TIMP levels, working memory, and gamma oscillation power in APOE4 targeted replacement mice

Greco GA, Rock M, Amontree M, Lanfranco MF, Kortha H, Hong SH, Turner RS, Rebeck GW and Conant K
Neurobiol Dis. 179:106057: 2023.
Full-Text Article
[ Journal Article ]

Pharmacokinetic modeling optimizes inhibition of the 'undruggable' EWS-FLI1 transcription factor in Ewing Sarcoma

Hong SH, Youbi SE, Hong SP, Kallakury B, Monroe P, Erkizan H, Barber-Rotenberg JS, Houghton P, Uren A and Toretsky JA
Oncotarget. 5(2): 338-350, 2014.
Full-Text Article
[ Journal Article ]

Modeling metastasis biology and therapy in real time in the mouse lung

Mendoza A, Hong SH, Osborne T, Khan MA, Campbell K, Briggs J, Eleswarapu A, Buquo L, Ren L, Hewitt SM, Dakir EH, Garfield S, Walker R, Merlino G, Green JE, Hunter KW, Wakefield LM and Khanna C
J Clin Invest. 120(8): 2979-88, 2010.
Full-Text Article
[ Journal Article ]