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Sue  Wickner, Ph.D.

Sue Wickner, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Molecular Biology

RESEARCH SUMMARY

Dr. Wickner's laboratory has contributed to the understanding of ATP-dependent protein machines essential for DNA replication, protein remodeling, and proteolysis. The current research goal of her group is to elucidate the mechanisms of action of energy-utilizing molecular chaperones in protein folding, protein activation and aggregate disassembly, and the role of chaperones in proteolysis. The ongoing work on Hsp90, Hsp70 and Clp/Hsp100 is providing the foundation to guide future research in the development of preventions and treatment for diseases involving misfolded, aggregated or inactive proteins, including cancer, Alzheimer’s, Parkinson’s, type II diabetes, cystic fibrosis and prion diseases.

Areas of Expertise

1) molecular chaperones 2) Hsp90 3) Hsp70 4) protein disaggregation 5) proteolysis 6) protein folding

Publications

Selected Recent Publications

Hsp90 of E. coli modulates assembly of FtsZ, the bacterial tubulin homolog

Balasubramanian A, Markovski M, Hoskins JR, Doyle SM, Wickner S.
Proc Natl Acad Sci U S A. 116(25): 12285-94, 2019. [ Journal Article ]

Structural basis for inhibition of a response regulator of σS stability by a ClpXP antiadaptor

Dorich V, Brugger C, Tripathi A, Hoskins JR, Tong S, Suhanovsky MM, Sastry A, Wickner S, Gottesman S, Deaconescu AM.
Genes Dev. 33(11-12): 718-32, 2019. [ Journal Article ]

Functional and Physical Interaction Between Yeast Hsp90 and Hsp70

Kravats AN, Hoskins JR, Reidy M, Johnson JL, Doyle SM, Genest O, Masison DC, Wickner S.
Proc Natl Acad Sci U S A. 115(10): E2210-19, 2018. [ Journal Article ]

Interaction of E. coli Hsp90 with DnaK Involves the DnaJ Binding Region of DnaK.

Kravats AN, Doyle SM, Hoskins JR, Genest O, Doody E, Wickner S.
J Mol Biol. 429(6): 858-72, 2017. [ Journal Article ]

Interplay between E. coli DnaK, ClpB and GrpE during protein disaggregation.

Doyle SM, Shastry S, Kravats AN, Shih YH, Miot M, Hoskins JR, Stan G, Wickner S.
J Mol Biol. 427(2): 312-27, 2015. [ Journal Article ]

Job Vacancies

There are no open positions at this time. Check back again later, or take a look at CCR's Careers page.

Team

Research Biologist
Joel Hoskins
Postdoctoral Fellow (CRTA)
Jui-Yun R. Liao, Ph.D.
Postbaccalaureate Fellow (CRTA)
Gabrielle Puller
Staff Scientist
Patrick G. Needham, Ph.D.
Postbaccalaureate Fellow (CRTA)
Kevin D. Nguyen, B.S.