Sue  Wickner, Ph.D.

Sue Wickner, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Molecular Biology


Dr. Wickner's laboratory has contributed to the understanding of ATP-dependent protein machines essential for DNA replication, protein remodeling, and proteolysis. The current research goal of her group is to elucidate the mechanisms of action of energy-utilizing molecular chaperones in protein folding, protein activation and aggregate disassembly, and the role of chaperones in proteolysis. The ongoing work on Hsp90, Hsp70 and Clp/Hsp100 is providing the foundation to guide future research in the development of preventions and treatment for diseases involving misfolded, aggregated or inactive proteins, including cancer, Alzheimer’s, Parkinson’s, type II diabetes, cystic fibrosis and prion diseases.

Areas of Expertise

Molecular Chaperones
Protein Disaggregation


Selected Recent Publications

Proteins form Binary Complexes with Hsp90 and Ternary Complexes with Hsp90 and Hsp70

Wickramaratne AC, Liao JY, Doyle SM, Hoskins JR, Puller G, Scott ML, Alao JP, Obaseki I, Dinan JC, Maity TK, Jenkins LM, Kravats AN, Wickner S
J Mol Biol. 435(17): 168-184, 2023. [ Journal Article ]

The Bacterial Hsp90 Chaperone: Cellular Functions and Mechanism of Action

Wickner S, Nguyen TL, Genest O
Annu Rev Microbiol. 75: 719-739, 2021. [ Journal Article ]

Functional and Physical Interaction Between Yeast Hsp90 and Hsp70

Kravats AN, Hoskins JR, Reidy M, Johnson JL, Doyle SM, Genest O, Masison DC, Wickner S.
Proc Natl Acad Sci U S A. 115(10): E2210-19, 2018. [ Journal Article ]

Uncovering a region of heat shock protein 90 important for client binding in E. coli and chaperone function in yeast

Genest O, Reidy M, Street TO, Hoskins JR, Camberg JL, Agard DA, Masison DC, Wickner S
Mol Cell. 49(3): 464-73, 2013. [ Journal Article ]

Heat shock protein 90 from Escherichia coli collaborates with the DnaK chaperone system in client protein remodeling

Genest O, Hoskins JR, Camberg JL, Doyle SM, Wickner S.
Proc Natl Acad Sci U S A. 108(20): 8206-11, 2011. [ Journal Article ]

Job Vacancies

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Research Biologist
Joel Hoskins, M.S.
Staff Scientist
Patrick G. Needham, Ph.D.
Postbaccalaureate Fellow (CRTA)
Ryan McLellan, B.S.
Postdoctoral Fellow (CRTA)
Anushka Wickramaratne, Ph.D.


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