Sergey G. Tarasov, Ph.D.

Sergey G. Tarasov, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Sergey G. Tarasov is overseeing the Biophysics Resource in the Center for Structural Biology, which provides CCR investigators with access to modern technologies and expertize in the area of biophysical chemistry. In this shared-use facility scientists get necessary training and perform their own experiments under supervision of expert staff, which provides technical or collaborative help with novel experimental design, data analysis and interpretation.

Areas of Expertise

1) biomolecular structure–property relationship, 2) biomolecular interactions, 3) biological thermodynamics, 4) molecular spectroscopy, 5) light scattering, 6) liquid chromatography and mass spectrometry


Selected Publications

Design and Generation of Self-Assembling Peptide Virus-like Particles with Intrinsic GPCR Inhibitory Activity

Sergey G Tarasov, Marzena Dyba , Joshua Yu , Nadya Tarasova
2208: 135-148, 2021. [ Book Chapter ]

Structural plasticity of a transmembrane peptide allows self-assembly into biologically active nanoparticles

Tarasov SG, Gaponenko V, Howard OM, Chen Y, Oppenheim JJ, Dyba MA, Subramaniam S, Lee Y, Michejda C, Tarasova NI.
Proc. Natl. Acad. Sci. U.S.A. 108: 9798-803, 2011. [ Journal Article ]

Bisimidazoacridones: 2. Steady-state and time-resolved fluorescence studies of their diverse interactions with DNA

Tarasov SG, Casas-Finet JR, Cholody WM, Kosakowska-Cholody T, Gryczynski ZK, Michejda CJ.
Photochem Photobiol. 78: 313-22, 2003. [ Journal Article ]

Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasome

Shi Y, Chen X, Elsasser S, Stocks BB, Tian G, Lee BH, Shi Y, Zhang N, de Poot SA, Tuebing F, Sun S, Vannoy J, Tarasov SG, Engen JR, Finley D, Walters KJ
Science. 351(6275): 831; pii: aad9421. doi: 10.1126/science.aad9421., 2016. [ Journal Article ]

Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallography

Stagno JR, Liu Y, Bhandari YR, Conrad CE, Panja S, Swain M, Fan L, Nelson G, Li C, Wendel DR, White TA, Coe JD, Wiedorn MO, Knoska J, Oberthuer D, Tuckey RA, Yu P, Dyba M, Tarasov SG, Weierstall U3, Grant TD, Schwieters CD, Zhang J, Ferré-D'Amaré AR, Fromme P, Draper DE, Liang M, Hunter MS, Boutet S, Tan K, Zuo X, Ji X, Barty A, Zatsepin NA6, Chapman HN, Spence JC, Woodson SA, Wang YX.
Nature. 541: 242-246, 2017. [ Journal Article ]