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Sankar  Adhya, Ph.D.

Sankar Adhya, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Molecular Biology

RESEARCH SUMMARY

Dr. Adhya's research interests focus on the modulation of transcription by DNA control elements and regulatory proteins such as repressors, activators, terminators, and antiterminators and their cognate signal molecules. Dr. Adhya and his team have demonstrated transcriptional regulation both at the level of initiation by activators and repressors and at the level of elongation by terminators and antiterminators in the gal operon, which encodes enzymes of D-galactose metabolims in Escherichia coli.

Areas of Expertise

1) gene regulation 2) regulatory proteins

Publications

Selected Recent Publications

Phage Resistance in Multidrug-Resistant Klebsiella pneumoniae ST258 Evolves via Diverse Mutations That Culminate in Impaired Adsorption.

Hesse S, Rajaure M, Wall E, Johnson J, Bliskovsky V, Gottesman S, Adhya S
mBio. 11(1): e02530-19, 2020. [ Journal Article ]

Molecular Basis of Phage Communication.

Rajaure M, Adhya S.
Mol Cell. 74(1): 1-2, 2019. [ Journal Article ]

Processing generates 3' ends of RNA masking transcription termination events in prokaryotes.

Wang X, N MPA, Jeon HJ, Lee Y, He J, Adhya S, Lim HM
Proc Natl Acad Sci U S A. 116(10): 4440-4445, 2019. [ Journal Article ]

DNA-RNA interactions are critical for chromosome condensation in Escherichia coli.

Qian Z, Zhurkin VB, Adhya S.
Proc Natl Acad Sci U S A. 114(46): 12225-30, 2017. [ Journal Article ]

Job Vacancies

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Team

Clinical Fellow
Shayla Hesse, M.D.
Postbaccalaureate Fellow (IRTA/CRTA)
Joy Johnson
Research Biologist
Phuoc Le
Staff Scientist
Dale E. Lewis, Ph.D.
Special Volunteer
Xintian Li, Ph.D.
Postdoctoral Fellow (Visiting)
Manoj Rajaure, Ph.D.
Research Biologist
Andrei Trostel
Postdoctoral Fellow (Visiting)
Subhash Verma, Ph.D.
Postdoctoral Fellow (CRTA)
Xiaoli Weng, Ph.D.