Ruibai  Luo, Ph.D.

Ruibai Luo, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Luo's current research interests include: kinetics studies of Arf-Arf GAP interactions leading to GTP hydrolysis; structural analysis of the interface of Arf-Arf GAP; and Arf GAP functions in membrane trafficking and remodeling of cytoskeleton.

Areas of Expertise

Kinetic Studies


Selected Publications

Kinetic analysis of Arf GAP1 indicates a regulatory role for coatomer

Luo R, Randazzo PA.
J. Biol. Chem.. 283: 21965-77, 2008. [ Journal Article ]

Arf GAP2 is positively regulated by coatomer and cargo

Luo R, Ha VL, Hayashi R, Randazzo PA.
Cell. Signal.. 21: 1169-79, 2009. [ Journal Article ]

GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity

Luo R, Akpan IO, Hayashi R, Sramko M, Barr V, Shiba Y, Randazzo PA.
J. Biol. Chem.. 287: 17176-85, 2012. [ Journal Article ]

Mutational analysis of the Arf1*GTP/Arf GAP interface reveals an Arf1 mutant that selectively affects the Arf GAP ASAP1

Luo R, Jacques K, Ahvazi B, Stauffer S, Premont RT, Randazzo PA.
Curr. Biol.. 15: 2164-9, 2005. [ Journal Article ]

Kinetic analysis of GTP hydrolysis catalysed by the Arf1-GTP-ASAP1 complex

Luo R, Ahvazi B, Amariei D, Shroder D, Burrola B, Losert W, Randazzo PA.
Biochem. J.. 402: 439-47, 2007. [ Journal Article ]