Breadcrumb

Renee N. Donahue, Ph.D.

Renee N. Donahue, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Center for Immuno-Oncology

RESEARCH SUMMARY

Dr. Donahue is a Staff Scientist and Head of the Cellular Immunology Group of the Center for Immuno-Oncology, NCI. She received her Ph.D. in Cell and Molecular Biology from the Pennsylvania State University College of Medicine, and joined the NCI as a Postdoctoral Fellow in 2011. The Cellular Immunology Group interrogates the human immunome of patients prior to immunotherapy and at various times in the immunotherapeutic regimen. Analyses include soluble factors, immune cell subset phenotype and functional assays, and responses to tumor-specific and tumor-associated antigens to help define mechanisms of action and correlates with patient clinical responses.

Areas of Expertise

1) cellular and molecular immunology 2) tumor immunology 3) cancer immunotherapy 4) immune biomarkers

Publications

Selected Key Publications

Immune correlates of clinical parameters in patients with HPV-associated malignancies treated with bintrafusp alfa

Tsai Y-T, Strauss J, Toney NJ, Jochems C, Gulley JL, Schlom J, Donahue RN
J ImmunoTher Cancer . 10(4): e004601, 2022.
Full-Text Article
[ Journal Article ]

Efficacy and tolerability of anti-programmed death-ligand 1 (PD-L1) antibody (avelumab) treatment in advanced thymoma

Rajan A, Heery CR, Thomas A, Mammen AL, Perry S, O’Sullivan Coyne G, Guha U, Berman A, Szabo E, Madan RA, Ballester LY, Pittaluga S, Donahue RN, Tsai Y-T, Lepone LM, Chin K, Ginty F, Sood A, Hewitt SM, Schlom J, Hassan R, Gulley JL
J ImmunoTher Cancer. 7: 269, 2019. [ Journal Article ]

Analyses of the peripheral immunome following multiple administrations of avelumab, a human IgG1 anti-PD-L1 monoclonal antibody

Donahue RN, Lepone LM, Grenga I, Jochems C, Fantini M, Madan RA, Heery CR, Gulley JL, Schlom J.
J Immunother Cancer. 5:20: 2017. [ Journal Article ]

Analyses of pretherapy peripheral immunoscore and response to vaccine therapy

Farsaci B, Donahue RN, Grenga I, Lepone LM, Kim PS, Dempsey B, Siebert JC, Ibrahim NK, Madan RA, Heery CR, Gulley JL, Schlom J.
Cancer Immunol Res. 4: 755-65, 2016. [ Journal Article ]

Analyses of 123 peripheral human immune cell subsets: defining differences with age and between healthy donors and cancer patients that are not detected in analysis of standard immune cell types

Lepone LM, Donahue RN, Grenga IG, Richards J, Metenou S, Heery CR, Madan RA, Gulley JL, Schlom J.
J. Circ Biomark. 5:5: [ Journal Article ]

Team

Postdoctoral Fellow (Visiting Fellow)
Carolina Celades Errando, M.D.
Meg Goswami, PhD
Postdoctoral Fellow (CRTA)
Meg Goswami, Ph.D.
Rachel L. Kazmierski
Biologist (Contr)
Rachel L. Kazmierski
Steffie Pitts
Post-doctoral Fellow (CRTA; iCURE program)
Stephanie C. Pitts, Ph.D.
Angie Schwab
Biologist
Angela Schwab
Nicole J. Toney, PhD
Postdoctoral Fellow (CRTA)
Nicole J. Toney, Ph.D.
Yo-Ting Tsai, PhD
Research Fellow
Yo-Ting Tsai , Ph.D.
Keanan Wright
Biologist (Contr.)
Keanan Wright