picture of Paul Randazzo

Paul A. Randazzo, M.D., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


The group studies Arf family guanine nucleotide binding proteins and their regulators Arf GTPase-activating proteins (Arf GAPs) and Arf guanine nucleotide exchange factors (Arf GEFs), with a focus on their function in the regulation of integrin adhesion complexes.

Areas of Expertise

Ras Superfamily Guanine Nucleotide Binding Proteins
ADP-Ribosylation Factor Guanine Nucleotide Binding Proteins (Arfs)
GTPase-Activating Proteins (GAPs)
Guanine Nucleotide Exchange Factors (GEFs)


Selected Recent Publications

ArfGAP3 regulates the transport of cation-independent mannose 6-phosphate receptor in the post-Golgi compartment

Shiba Y, Kametaka S, Waguri S, Presley JF, Randazzo PA.
Curr. Biol. 23: 1945-51, 2013. [ Journal Article ]

ARAP2 signals through Arf6 and Rac1 to control focal adhesion morphology

Chen P, Jian X, Yoon H, Randazzo PA.
J. Biol. Chem. 288: 5849-60, 2013. [ Journal Article ]

Approaches to studying Arf GAPs in cells: in vitro assay with isolated focal adhesions

Chen P, Jian X, Luo R, Randazzo PA.
Curr Protoc Cell Biol. Chapter 17: Unit 17.13, 2012. [ Journal Article ]

The ArfGAP ASAP1 Controls Actin Stress Fiber Organization via Its N-BAR Domain

Gasilina A, Vitali T, Luo R, Jian X, Randazzo PA
iScience. 22: 166-180, 2019.
Full-Text Article
[ Journal Article ]

Job Vacancies

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Post-Baccalaureate Fellow (CRTA)
Emily Andersen
Senior Research Assistant
Xiaoying Jian, Ph.D.
Post-Doctoral Fellow (CRTA)
Eric Rosenberg, Ph.D.
Research Fellow (Visiting)
Mukesh Yadav, Ph.D.
Scientist (Contractor)
Hye-Young Yoon, Ph.D.
Post-Doctoral Fellow
Sarah Hammoudeh, PhD


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