Orieta Celiku, Ph.D.
- Center for Cancer Research
- National Cancer Institute
- Building 37, Room 1142B
- Bethesda, MD 20814
Dr. Celiku develops and applies integrative computational approaches to better understand and treat primary brain cancers. Her research focus includes 1) Development of computational models to understand how genomic and epigenomic alterations affect tumor biology and behavior, 2) Development of semantic and machine learning approaches for characterizing molecular profiles of preclinical models alongside profiles of patient tumors, assessing how well these models recapitulate human disease, and how they can inform rational selection of therapies, 3) Development of cancer patient genomic and outcomes data integration and visualization tools to facilitate data exploration for bench scientists and clinicians, and 4) Development of tools that enable primary brain tumor patients and their caregivers to track and manage their symptoms. Dr. Celiku's research approach is driven by the conviction that solid computational principles that have stood the test of time are indispensable tools for tackling the complexity of precision oncology.
Areas of Expertise
1) computer science 2) bioinformatics
Association of circadian clock gene expression with glioma tumor microenvironment and patient survival.
Computational modeling demonstrates that glioblastoma cells can survive spatial environmental challenges through exploratory adaptation.
Orieta Celiku, Ph.D.
Dr. Celiku holds a Ph.D. in Computer Science from Åbo Akademi University where she developed formal verification tools for reasoning about behavior of nondeterministic computer programs, and a Master's in Biochemistry and Molecular Biology from Georgetown University. Prior to joining the Neuro-Oncology Branch (NOB), she completed postdoctoral training in software engineering and architecture at the School of Computer Science of Carnegie Mellon University, followed by training in bioinformatics at the Radiation Oncology Branch of National Cancer Institute where she developed bioinformatics tools for integrating and visualizing cancer genomic data. Dr. Celiku joined NOB in 2016 as a research fellow and was subsequently promoted to staff scientist.