Breadcrumb

Orieta Celiku

Orieta Celiku, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Neuro-Oncology Branch

RESEARCH SUMMARY

Dr. Celiku develops and applies integrative computational approaches to better understand and treat primary brain cancers. Her research focus includes 1) Development of computational models to understand how genomic and epigenomic alterations affect tumor biology and behavior, 2) Development of semantic and machine learning approaches for characterizing molecular profiles of preclinical models alongside profiles of patient tumors, assessing how well these models recapitulate human disease, and how they can inform rational selection of therapies, 3) Development of cancer patient genomic and outcomes data integration and visualization tools to facilitate data exploration for bench scientists and clinicians, and 4) Development of tools that enable primary brain tumor patients and their caregivers to track and manage their symptoms. Dr. Celiku's research approach is driven by the conviction that solid computational principles that have stood the test of time are indispensable tools for tackling the complexity of precision oncology.

Areas of Expertise

1) computer science 2) bioinformatics

Publications

Selected Key Publications

Association of circadian clock gene expression with glioma tumor microenvironment and patient survival.

De La Cruz Minyety J, Shuboni-Mulligan DD, Briceno N, Young D, Gilbert MR, Celiku O, Armstrong TS.
Cancers. 13(11): 2756, 2021. [ Journal Article ]

Molecularly targeted clinical trials.

Smith-Cohn MA, Celiku O, Gilbert MR.
Neurosurgery Clinics of North America. 32(2): 191-210, 2021. [ Journal Article ]

Computational modeling demonstrates that glioblastoma cells can survive spatial environmental challenges through exploratory adaptation.

Celiku O, Gilbert MR, Lavi O.
Nature Communications. 10(1): 5704, 2019. [ Journal Article ]

Computational analysis of the mesenchymal signature landscape in gliomas.

Celiku O., Tandle A., Chung J-Y, Hewitt SM, Camphausen K, Shankavaram U.
BMC Medical Genomics. 10(1): 13, 2017. [ Journal Article ]

Visualizing molecular profiles of glioblastoma with GBM-BioDP.

Celiku O, Johnson S, Zhao S, Camphausen K, Shankavaram U.
PLoS One. 9(7): e101239, 2014. [ Journal Article ]

Team

POSTBACCALAUREATE FELLOW (IRTA/CRTA)
Brandon Bergsneider
IRTA/CRTA Fellow
Yeonju Kim
Biologist
Aiguo Li, Ph.D.
IRTA/CRTA Fellow
Hope Miller
Application Developer
Mahendar Ramidi