Orieta Celiku, Ph.D.
- Center for Cancer Research
- National Cancer Institute
- Building 37, Room 1142B
- Bethesda, MD 20814
Dr. Celiku develops and applies integrative computational approaches to better understand and treat primary brain cancers. Her research in the Translational Immunology Research Program at the Neuro-Oncology Branch (NOB) is driven by the conviction that solid computational principles that have stood the test of time are indispensable tools for tackling the complexity of precision oncology. Her research focuses are:
- Developing computational models to understand how genomic and epigenomic alterations affect tumor biology and behavior
- Developing semantic and machine learning approaches for characterizing molecular profiles of preclinical models alongside profiles of patient tumors—in order to assess how well these models recapitulate human disease, and how they can inform rational selection of therapies
- Developing cancer patient genomic and outcomes data integration and visualization tools to facilitate data exploration for bench scientists and clinicians
- Developing tools that enable primary brain tumor patients and their caregivers to track and manage their symptoms
Areas of Expertise
Computer science | Bioinformatics
Discovery of clinical and demographic determinants of symptom burden in primary brain tumor patients using network analysis and unsupervised clustering
Computational modeling demonstrates that glioblastoma cells can survive spatial environmental challenges through exploratory adaptation.
Orieta Celiku, Ph.D.
Dr. Celiku holds a Ph.D. in computer science from Åbo Akademi University in Finland, where she developed formal verification tools for reasoning about behavior of nondeterministic computer programs. She also holds a master's in biochemistry and molecular biology from Georgetown University. Prior to joining the Translational Immunology Program at the Neuro-Oncology Branch (NOB), she completed her postdoctoral training in software engineering and architecture at the Carnegie Mellon University School of Computer Science, followed by training in bioinformatics at the NCI Center for Cancer Research’s Radiation Oncology Branch, where she developed bioinformatics tools for integrating and visualizing cancer genomic data. Dr. Celiku joined the NOB in 2016 as a research fellow and was subsequently promoted to staff scientist.