Nyall R. London Jr., M.D., Ph.D.
- Center for Cancer Research
- National Cancer Institute
- Building 10 - Clinical Center, Room 7N240
- Bethesda, MD 20892
- 301-402-4216
- nyall.london@nih.gov
RESEARCH SUMMARY
Dr. London is an otolaryngology surgeon-scientist with expertise in disorders and cancers involving the nasal cavity, sinuses, and base of the skull.
Areas of Expertise
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Nyall R. London Jr., M.D., Ph.D.
Research
Our laboratory is focused on understanding how and why head and neck cancers develop in the nasal cavity, sinuses, and base of the skull. We seek to translate these results into better therapies. We are particularly interested in a type of cancer called olfactory neuroblastoma (also known as esthesioneuroblastoma), which researchers think arises from the olfactory epithelium, the area of the nose important for the sense of smell.
The goals of the Sinonasal and Skull Base Tumor Program are to 1) understand the impact that standard surgical, radiation and chemotherapy treatments have on the sense of smell, 2) identify critical genes that drive tumor development, and determine their mechanism of action and 3) assess the potential of these genes as therapeutic targets.
Our laboratory utilizes a variety of in vitro and in vivo experimental approaches and immunotherapeutic and other treatment platforms to achieve these goals. We are actively developing a series of clinical trials to improve treatment effectiveness and survival in patients with sinonasal and skull base cancers.
Publications
Combinatorial Natural Killer Cell-based Immunotherapy Approaches Selectively Target Chordoma Cancer Stem Cells
The genomics and epigenetics of olfactory neuroblastoma: A systematic review
Expression of Programmed Cell Death Ligand 1 and Associated Lymphocyte Infiltration in Olfactory Neuroblastoma
Clinical outcomes, Kadish-INSICA staging and therapeutic targeting of somatostatin receptor 2 in olfactory neuroblastoma
Biography
Nyall R. London Jr., M.D., Ph.D.
Dr. London received a bachelor’s degree in microbiology from Brigham Young University in Utah, and then an M.D. and a Ph.D. in oncological sciences from the University of Utah, Salt Lake City. During his Ph.D., under the guidance of Dr. Dean Y. Li, he received an NIH multidisciplinary cancer research training grant, which trains Ph.D. students in clinical and molecular mechanisms of cancer biology.
He then completed his otolaryngology–head and neck surgery residency training at the Johns Hopkins University School of Medicine, where he received the Frank L. Coulson Jr. Award for Clinical Excellence and the Duane Sewell Resident Award for Exemplary Professionalism and Humanitarianism. He completed a fellowship in open and endoscopic skull base surgery at The Ohio State University College of Medicine under the direction of Dr. Ricardo L. Carrau.
In 2019, he joined the National Institute on Deafness and Other Communication Disorders (NIDCD) as an investigator in the Otolaryngology Surgeon-Scientist Program, a mentored, junior-faculty career development program. Dr. London joined CCR in 2022.
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