Dr. Nagarsheth Close Up Photo

Nisha B. Nagarsheth, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Nagarsheth joined the ID-CTP as a Staff Scientist in 2021. She studies immune deficiencies (such as DOCK8, WAS, and various types of SCID disorders) and develops effective treatments, which include tailored cellular therapy and hematopoietic stem cell transplant. She examines immune cell crosstalk, functionality, and reconstitution over time after treatment, with the goal of improving treatment for these disorders. Her research also focuses on understanding basic immune cell function and biology through studying these deficiencies.

Areas of Expertise

Human Immunology
Inborn Errors Of Immunity
Gene And Cellular Therapy
Clinical Immunology Research
Cancer Immunotherapy
Tumor Immunology


Selected Key Publications

TCR-engineered T cells targeting E7 for patients with metastatic HPV-associated epithelial cancers

Nagarsheth NB, Norberg SM, Sinkoe AL, Adhikary S, Meyer TJ, Lack JB, Warner AC, Schweitzer C, Doran SL, Korrapati S, Stevanović S, Trimble CL, Kanakry JA, Bagheri MH, Ferraro E, Astrow SH, Bot A, Faquin WC, Stroncek D, Gkitsas N, Highfill S, Hinrichs CS.
Nature Medicine. 27/3: 419-425, 2021.
Full-Text Article
[ Journal Article ]

Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy

Nagarsheth N, Wicha MS, Zou W.
Nature Review Immunology. 17/9: 559-572, 2017.
Full-Text Article
[ Journal Article ]

PRC2 Epigenetically Silences Th1-Type Chemokines to Suppress Effector T-Cell Trafficking in Colon Cancer

Nagarsheth N, Peng D, Kryczek I, Wu K, Li W, Zhao E, Zhao L, Wei S, Frankel T, Vatan L, Szeliga W, Dou Y, Owens S, Marquez V, Tao K, Huang E, Wang G, Zou W.
Cancer Research. 76/2: 275-282, 2016.
Full-Text Article
[ Journal Article ]

Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy

Peng D, Kryczek I, Nagarsheth N, Zhao L, Wei S, Wang W, Sun Y, Zhao E, Vatan L, Szeliga W, Kotarski J, Tarkowski R, Dou Y, Cho K, Hensley-Alford S, Munkarah A, Liu R, Zou W.
Nature. 527/7577: 249-253, 2015.
Full-Text Article
[ Journal Article ]

IL-22+CD4+ T Cells Promote Colorectal Cancer Stemness via STAT3 Transcription Factor Activation and Induction of the Methyltransferase DOT1L

Kryczek I, Lin Y, Nagarsheth N, Peng D, Zhao L, Zhao E, Vatan L, Szeliga W, Dou Y, Owens S, Zgodzinski W, Majewski M, Wallner G, Fang J, Huang E, Zou W.
Immunity. 40/5: 772-784, 2014.
Full-Text Article
[ Journal Article ]