Myriem Boufraqech, Ph.D.

Myriem Boufraqech, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Surgical Oncology Program


Dr. Myriem Boufraqech is a molecular biologist who investigates the molecular events governing the progression of thyroid cancer. Research in her group aims to enhance the understanding of thyroid cancer progression and metastasis and to elucidate the mechanisms of resistance to targeted therapy. Dr. Boufraqech uses genomics and transcriptomics tools both in vitro and in vivo to identify the key molecular events governing thyroid cancer dedifferentiation and resistance to therapy. Dr. Boufraqech’s goal is to identify determinants of resistance to targeted therapy in anaplastic (undifferentiated) thyroid cancer.

Areas of Expertise

Thyroid Cancer
Cancer Biology
Targeted Therapy
Cell Signaling


Selected Key Publications

miR30a inhibits LOX expression and anaplastic thyroid cancer progression

Boufraqech M , Nilubol N , Zhang L , Gara SK , Sadowski SM , Mehta A , He M , Davis S , Dreiling J , Copland JA, Smallridge RC, Quezado MM , Kebebew E
Cancer Research. 75(2): 367-77, [ Journal Article ]

Lysyl Oxidase expression is regulated by the BRAF/MAPK pathway and is a prognostic marker in thyroid cancer

Boufraqech M, Patel D, Nilubol N,Power A, King T, Shell J, Lack J, Zhang L, Gara SK, Gunda V, Klubo-Gwiezdzinska J, Kumar S, Fagin J, Knauf J, Parangi S, Venzon D, Quezado MM, Kebebew E
Thyroid. 29(1): 79-92, [ Journal Article ]

New Therapies for Advanced Thyroid Cancer

Laha D, Nilubol N, Boufraqech M.
Front Endocrinol. 11: 82, 2020. [ Journal Article ]

Lysyl Oxidase (LOX) transcriptionally regulates SNAI2 expression and TIMP4 secretion in human cancers

Boufraqech M ,Zhang L , Nilubol N , Sadowski SM , Kotian S , Quezado M , Kebebew E
Clinical cancer Research. 22(17): 491–4504, [ Journal Article ]
[ Journal Article ]

Job Vacancies

Position Degree Required Contact Name Contact Email
Postdoctoral Fellow - Anaplastic thyroid cancer, CRISPR screen Ph.D. or equivalent, M.D. or equivalent Myriem Boufraqech


Olivia White, B.S.