Murali Palangat Ph.D.

Murali Palangat Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


My two primary research areas of interest are (i) understanding the structure-function of splicing factor U2AF-RNA interactions during translation and how its regulation controls gene expression and, (ii) how the cancer associated splicing factor mutations alter RNA fate leading to control of gene expression and their role in cancer biology.

Areas of Expertise

Biochemistry And Molecular Bology
Single Molecule Transcription
In Vivo Live Cell Imaging


Selected Publications

The splicing factor U2AF1 contributes to cancer progression through a noncanonical role in translation regulation

Palangat M, Anastasakis DG, Fei DL, Lindblad KE, Bradley R, Hourigan CS, Hafner M, Larson DR
Genes and Development. DOI: 10.1101/gad.319590.118: 2019. [ Journal Article ]

The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription

Navdeep Malik, Hualong Yan, Nellie Moshkovich, Murali Palangat, Howard Yang, Vanesa Sanchez, Zhuo Cai, Tyler J. Peat, Shunlin Jiang, Chengyu Liu, Maxwell Lee, Beverly A. Mock, Stuart H. Yuspa, Daniel Larson, Lalage M. Wakefield & Jing Huang
Nature Communications. 10: 2071-2086, 2019. [ Journal Article ]

Single-Gene Dual-Color Reporter Cell Line to Analyze RNA Synthesis in vivo

Palangat M and Larson DR
Methods “RNA Structure Determination”. 2016. [ Journal Article ]

Kinetic competition during the transcription cycle results in stochastic RNA processing

Coulon A, Ferguson ML, de Turris V, Palangat M, Chow CC, Larson DR
Elife. 2014. [ Journal Article ]

Trigger-helix folding pathway and SI3 mediate catalysis and hairpin-stabilized pausing by Escherichia coli RNA polymerase

Windgassen TA, Mooney RA, Nayak D, Palangat M, Zhang J, Landick R
Nucl. Acids Res. 42: 12707-12721, 2014. [ Journal Article ]