Murali Palangat Ph.D.
- Center for Cancer Research
- National Cancer Institute
- Building 41, Room B303
- Bethesda, MD 20892
- 240-760-6692
- murali.palangat@nih.gov
Senior Research Assistant
RESEARCH SUMMARY
My two primary research areas of interest are (i) understanding the structure-function of splicing factor U2AF-RNA interactions during translation and how its regulation controls gene expression and, (ii) how the cancer associated splicing factor mutations alter RNA fate leading to control of gene expression and their role in cancer biology.
Areas of Expertise
Biochemistry And Molecular Bology
Single Molecule Transcription
In Vivo Live Cell Imaging
Murali Palangat Ph.D.
Publications
- Bibliography Link
- https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/
Selected Publications
The splicing factor U2AF1 contributes to cancer progression through a noncanonical role in translation regulation
Genes and Development.
DOI: 10.1101/gad.319590.118:
2019.
[ Journal Article ]
The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription
Nature Communications.
10:
2071-2086,
2019.
[ Journal Article ]
Single-Gene Dual-Color Reporter Cell Line to Analyze RNA Synthesis in vivo
Methods “RNA Structure Determination”.
2016.
[ Journal Article ]
Kinetic competition during the transcription cycle results in stochastic RNA processing
Elife.
2014.
[ Journal Article ]
Trigger-helix folding pathway and SI3 mediate catalysis and hairpin-stabilized pausing by Escherichia coli RNA polymerase
Nucl. Acids Res.
42:
12707-12721,
2014.
[ Journal Article ]