Mikhail Kolmogorov

Mikhail Kolmogorov, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Cancer Data Science Laboratory


The focus of Dr. Kolmogorov’s laboratory research is computational genomics -- algorithms, mathematical models and tools aimed at answering fundamental questions about living systems through the analysis of large-scale sequencing data.

Areas of Expertise

Computational Genomics
Bioinformatics Algorithms
Long-Read DNA Sequencing
Big Data Analysis


Selected Key Publications

Assembly of long, error-prone reads using repeat graphs

Kolmogorov M, Yuan J, Lin Y, Pevzner PA.
Nat Biotechnol. 37(5): 540-546, 2019. [ Journal Article ]

metaFlye: scalable long-read metagenome assembly using repeat graphs

Kolmogorov M, Bickhart DM, Behsaz B, Gurevich A, Rayko M, Shin SB, Kuhn K, Yuan J, Polevikov E, Smith TPL, Pevzner PA
Nat Methods. 17(11): 1103-1110, 2020. [ Journal Article ]

Chromosome assembly of large and complex genomes using multiple references

Kolmogorov M, Armstrong J, Raney BJ, Streeter I, Dunn M, Yang F, Odom D, Flicek P, Keane TM, Thybert D, Paten B, Pham S.
Genome Res. 28(11): 1720-1732, 2018. [ Journal Article ]

Assembly of long error-prone reads using de Bruijn graphs

Lin Y, Yuan J, Kolmogorov M, Shen MW, Chaisson M, Pevzner PA.
Proc Natl Acad Sci U S A. 113(52): E8396-E8405, 2016. [ Journal Article ]

Generating lineage-resolved, complete metagenome-assembled genomes from complex microbial communities

Derek M Bickhart, Mikhail Kolmogorov, Elizabeth Tseng, Daniel M Portik, Anton Korobeynikov, Ivan Tolstoganov, Gherman Uritskiy, Ivan Liachko, Shawn T Sullivan, Sung Bong Shin, Alvah Zorea, Victòria Pascal Andreu, Kevin Panke-Buisse, Marnix H Medema, Itzhak Mizrahi, Pavel A Pevzner, Timothy P L Smith.
Nature Biotechnology . 24, 2022.
Full-Text Article
[ Journal Article ]

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