Maria  Miller, Ph.D.

Maria Miller, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Center for Structural Biology


Dr. Miller is a structural biologist who is investigating the three-dimensional structures, conformational transitions and intermolecular interactions of proteins and nucleic acids. She played a critical role in solving the crystal structures of proteases from the Rous sarcoma virus (RSV) and human immunodeficiency virus type 1 (HIV-1) retroviruses (Peptide Science, 94: 521-9, 2010).

Areas of Expertise

1) X-ray crystallography, 2) structural bioinformatics, 3) protein sequence analysis, 4) protein-DNA interactions, 5) intrinsically disordered proteins


Selected Key Publications

Crystal structure of 15-mer DNA duplex containing unpaired bases

Miller M, Harrison RW, Wlodawer A, Appella E, Sussman JS.
Nature. 334: 85-6, 1988. [ Journal Article ]

Structure of complex of synthetic HIV-1 protease with a substrate-based inhibitor at 2.3 Å resolution

Miller M, Schneider J, Sathyanarayana BK, Toth MV, Marshall GR, Clawson L, Selk L, Kent SB, Wlodawer A.
Science. 246: 1149-52, 1989. [ Journal Article ]

Crystal structure of a retroviral protease proves relationship to aspartic protease family

Miller M, Jaskólski M, Mohana Rao JK , Leis J, Wlodawer A.
Nature. 337: 576-9, 1989. [ Journal Article ]

Structural basis for DNA recognition by the basic region leucine zipper transcription factor CCAAT/enhancer-binding protein alpha

Miller M, Shuman JD, Sebastian T, Dauter Z, Johnson PF.
J Biol Chem. 278: 15178-84, 2003. [ Journal Article ]

Structural insights into interactions of C/EBP transcriptional activators with Taz2 domain of p300

Bhaumik P, Davis J, Tropea JE, Cherry S, Johnson PF, Miller M.
Acta Crystallogr D Biol Crystallogr. D70: 1914-21, 2014. [ Journal Article ]