Breadcrumb

Lyuba  Varticovski, M.D.

Lyuba Varticovski, M.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Our laboratory pioneered the analysis of global chromatin landscape using DnaseI hypersensitive sites (sites in the entire mammalian genome that are accessible to interaction with regulatory elements at any time) in normal and cancer cells, and their changes in response to drugs and activation of nuclear receptors. We adapted this method to probe global chromatin modifications during differentiation of stem cells into osteogenic lineage, a process that requires glucocorticoids, in characterizing metastatic potential, and acquisition of drug resistance.

Areas of Expertise

1) cancer biology, 2) chromatin biology, 3) nuclear receptors, 4) anticancer drug
development, 5) bone differentiation

Publications

Selected Publications

High Quality ATAC-Seq Data Recovered from Cryopreserved Breast Cell Lines and Tissue.

Fujiwara S, Baek S, Varticovski L, Kim S, Hager GL.
Sci Rep.. 2019. [ Journal Article ]

High Quality ATAC-Seq Data Recovered from Cryopreserved Breast Cell Lines and Tissue.

Fujiwara S, Baek S, Varticovski L, Kim S, Hager GL.
Scientific Reports. 9(1):516: 1-12, 2019. [ Journal Article ]

Prevalent glucocorticoid and androgen activity in US water sources

Stavreva DA, George AA, Klausmeyer P, Varticovski L, Sack D, Voss TC, Schiltz RL, Blazer VS, Iwanowicz LR, and Hager GL.
Sci Rep. 2: 937-40, 2012. [ Journal Article ]

Targeted H3R26 deimination specifically facilitates estrogen receptor binding by modifying nucleosome structure

Guertin MJ, Zhang X, Anguish L, Kim A, Varticovski L, Lis JT, Hager GL, and Coonrod SA
PLoS Genet. 10(9): e1004613, 2014. [ Journal Article ]

A quantitative high-throughput assay for detection of biologically active endocrine-disrupting chemicals in water

Stavreva D, Varticovski L, and Hager GL.
DE Reisner and T Pradeep, eds: 2014. [ Book Chapter ]