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Liqiang  Xi, M.D.

Liqiang Xi, M.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Pathology

RESEARCH SUMMARY

Dr. Xi worked with a translational clinical research team for 8 years at the University of Pittsburgh School of Medicine and later at the Mount Sinai School of Medicine, New York. This research was focused on identification of molecular markers to reliably detect cancer metastasis to lymph nodes or blood, and on molecular signatures of cancer by employing the cutting-edge technologies at the time, such as TaqMan real-time quantitative RT-PCR, gene expression microarrays, microRNA expression profiling, and genome wide whole exon microarrays.

At the NCI, Dr. Xi serves as the technical director for the Molecular Diagnostics Laboratory, Laboratory of Pathology, supervising a broad array of CLIA-certified molecular diagnostics activities from traditional fragment analysis for detection of B cell and T cell clonality in lymphoma and RT-PCR assays for fusion gene detection in sarcoma, to cancer gene mutation testing using the most cutting-edge technology, next generation sequencing.

Areas of Expertise

1) lymphoma, 2) sarcoma, 3) gene mutation

Publications

Selected Publications

Mutations in the JAK/STAT and RAS signaling pathways are common in intestinal T-cell lymphomas

Nicolae A, Xi L, Pham TH, Pham TA, Navarro W, Meeker HG, Pittaluga S, Jaffe ES, Raffeld M
Leukemia. doi: 10.1038/leu.2016.178: 2016. [ Journal Article ]

Circulating Tumor DNA as an Early Indicator of Response to T-Cell Transfer Immunotherapy in Metastatic Melanoma

Xi L, Pham T, Payabyab EC, Sherry RM, Rosenberg SA, Raffeld M
Clin Cancer Res.. pii: clincanres.0613.2016: 2016. [ Journal Article ]

Somatic STAT5b gain of function mutations in early-onset non-clonal eosinophilia, urticaria, dermatitis and diarrhea

Ma CA*, Xi L*, Cauff B, DeZure A, Freeman AF, Hambleton S, Kleiner G, Leahy TR, O'Sullivan M, Makiya M, O'Regan G, Pittaluga S, Niemela J, Stoddard J, Rosenzweig SD, Raffeld M, Klion AD, Milner JD
Blood. pii: blood-2016-09-737817: 2016. [ Journal Article ]

Both variant and IGHV4-34-expressing hairy cell leukemia lack the BRAF V600E mutation

Xi L, Arons E, Navarro W, Calvo KR, Stetler-Stevenson M, Raffeld M, Kreitman RJ.
Blood. 119: 3330-2, 2012. [ Journal Article ]

Concurrent molecular alterations in tumors with germ line epidermal growth factor receptor T790M mutations

Thomas A, Xi L, Carter CA, Rajan A, Khozin S, Szabo E, Dennis PA, Giaccone G, Raffeld M.
Clin Lung Cancer. 14: 452-6, 2013. [ Journal Article ]