Lin Du, Ph.D.

Lin Du, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
  • Building 562, Room 201
  • Frederick, MD 21702-1201
  • 301-228-4961
Molecular Targets Program


Dr. Du’s research is focused on the discovery and optimization of novel bioactive secondary metabolites from filamentous fungi and other natural sources. Dr. Du is also interested in the studies of mechanism of actions by generating natural product-based probes and computational modeling.

Areas of Expertise

Natural Products Chemistry
Medicinal Chemistry
Quantum Chemical Calculations
Computational Modeling


Selected Key Publications

Elucidating target specificity of the taccalonolide covalent microtubule stabilizers employing a combinatorial chemical approach

Du L, Yee SS, Ramachandran K, Risinger AL.
Nature Communications. 1(1): 654, 2020. [ Journal Article ]

Unique amalgamation of primary and secondary structural elements transform peptaibols into potent bioactive cell-penetrating peptides

Du L, Risinger AL, Mitchell CA, You J, Stamps BW, Pan N, King JB, Bopassa JC, Judge SIV, Yang Z, Stevenson BS, Cichewicz RH.
Proc Natl Acad Sci U S A. 114(43): E8957-E8966, 2017. [ Journal Article ]

Chemoreactive Natural Products that Afford Resistance Against Disparate Antibiotics and Toxins

Du L, You J, Nicholas KM, Cichewicz RH.
Angew Chem Int Ed Engl. 55(13): 4220-5, 2016. [ Journal Article ]

Crowdsourcing natural products discovery to access uncharted dimensions of fungal metabolite diversity

Du L, Robles AJ, King JB, Powell DR, Miller AN, Mooberry SL, Cichewicz RH.
Angew Chem Int Ed Engl. 53(3): 804-9, 2014. [ Journal Article ]

Unprecedented citrinin trimer tricitinol B functions as a novel topoisomerase IIα inhibitor

Du L, Liu HC, Fu W, Li DH, Pan QM, Zhu TJ, Geng MY, Gu QQ.
J Med Chem. 54(16): 5796-810, 2011. [ Journal Article ]


Quan Trong Khong
Postdoctoral Fellow
Quan Trong Khong, Ph.D.
Nasim Masoumeh Dalilian
Research Associate III
Masoumeh Nasim Dalilian, B.S.
Ji-yeon Hwang
Visiting Fellow
Ji-yeon Hwang, Ph.D.
Research Fellow
Dongdong Wang, Ph.D.