Leslie N. Aldrich, B.S., Ph.D.

Leslie N. Aldrich, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Molecular Targets Program


I am a medicinal chemist and chemical biologist with a research focus in probe and drug discovery. Our group studies complex biological phenomena using novel small molecules to identify new therapeutic strategies for unmet medical needs. A main area of interest for our lab is the study of the autophagy pathway, a self-recycling process that is critical to maintaining cellular homeostasis and innate immunity in the body. Defects in autophagy have been implicated in a number of human diseases, including inflammatory diseases, infectious diseases, neurodegenerative diseases and cancer. The small-molecule probes we develop in our lab facilitate our exploration of autophagy in the context of basic biology and human disease.

Areas of Expertise


Selected Recent Publications

Discovery of a Small-Molecule Modulator of the Autophagy-Lysosome Pathway That Targets Lamin A/C and LAMP1, Induces Autophagic Flux, and Affects Lysosome Positioning in Neurons

Hippman RS, Snead AM, Petros ZA, Korkmaz-Vaisys MA, Patel S, Sotelo D, Dobria A, Salkovski M, Nguyen TTA, Linares R, Cologna SM, Gowrishankar S, Aldrich LN
ACS Chem Neurosci. 14(24): 4363-4382, 2023. [ Journal Article ]

Development of a High-Throughput, Compound-Multiplexed Fluorescence Polarization Assay to Identify ATG5-ATG16L1 Protein-Protein Interaction Inhibitors

Salkovski M, Pavlinov I, Gao Q, Aldrich LN
SLAS Discov. 26(7): 933-943, 2021. [ Journal Article ]

Beclin 1-ATG14L Protein-Protein Interaction Inhibitor Selectively Inhibits Autophagy through Disruption of VPS34 Complex I

Pavlinov I, Salkovski M, Aldrich LN
J Am Chem Soc. 142(18): 8174-8182, 2020. [ Journal Article ]

Multiple Chemical Features Impact Biological Performance Diversity of a Highly Active Natural Product-Inspired Library

Hippman RS, Pavlinov I, Gao Q, Mavlyanova MK, Gerlach EM, Aldrich LN
Chembiochem. 21(21): 3137-3145, 2020. [ Journal Article ]

Next generation diversity-oriented synthesis: a paradigm shift from chemical diversity to biological diversity

Pavlinov I, Gerlach EM, Aldrich LN
Org Biomol Chem. 17(7): 1608-1623, 2019. [ Journal Article ]

Job Vacancies

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Predoctoral Fellow (Graduate Student)
Andrew Dobria
Predoctoral Fellow (Graduate Student)
Andrea Arrieche Suarez
Research Fellow
Ivan Pavlinov, PhD


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