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Jung-Eun  Park, Ph.D.

Jung-Eun Park, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Park's primary research interest lies in understanding the physiological functions of two functionally distinct mammalian polo-like kinases, Plk1 and Plk4, which appear to play key roles in mitotic progression and centriole duplication, respectively. Dr. Park is also interested in developing anti-Plk1 therapeutic agents by exploiting both potential leads from our own research and from the unique resources that NCI provides to the intramural community.

Areas of Expertise

kinases

Publications

Selected Publications

Phase separation of Polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis

Park JE, Zhang L, Bang JK, Andresson T, DiMaio F, Lee KS.
Nat Commun. 10(1): 4959, 2019. [ Journal Article ]

Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis

Park SY*, Park JE*, Kim TS*, Kim JH*, Kwak MJ*, Ku B*, Tian L, Murugan RN, Ahn M, Komiya S, Hojo H, Kim NH, Kim BY, Bang JK, Erikson RL, Lee KW, Kim SJ, Oh BH, Yang W, Lee KS.
Nat. Struct. Mol. 21(8): 696-703, 2014. [ Journal Article ]

Feed-forward mechanism of converting biochemical cooperativity to mitotic processes at the kinetochore plate

Park JE, Erikson RL, Lee KS.
Proc. Natl. Acad. Sci. U.S.A. 108: 8200-5, 2011. [ Journal Article ]

Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel

Liu F*, Park JE*, Qian W, Lim D, Graber M, Berg T, Yaffe MB, Lee KS*, Burke TR*.
Nat. Chem. Biol. 7: 595-601, 2011. [ Journal Article ]

Direct quantification of polo-like kinase 1 activity in cells and tissues using a highly sensitive and specific ELISA assay

Park JE, Li L, Park J, Knecht R, Strebhardt K, Yuspa SH, Lee KS.
Proc. Natl. Acad. Sci. U.S.A. 106: 1725-30, 2009. [ Journal Article ]