Joseph J. Barchi Jr., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Chemical Biology Laboratory


Dr Barchi’s career at the NCI has spanned a wide breadth of drug discovery efforts, including the synthesis of PKC and reverse transcriptase inhibitors, the development of glycopeptide antigens as vaccine candidates against HIV and cancer, as well as the discovery of several glycopeptide-analogues of Antiproliferative Factor (APF), a negative growth factor isolated from patients with interstitial cystitis. Current focus in the lab is the discovery of novel nanoplatforms for the delivery and therapeutic applications of immunogenic glycopeptides, the search for selective antitumor agents based on APF and the conformational analysis of these synthetic analogues by NMR spectroscopy to guide further discovery efforts.

Areas of Expertise

Synthetic Organic Chemistry
Small Molecule NMR Spectroscopy


Selected Key Publications

A Tumor-Selective Monoclonal Antibody from Immunization with a Tumor-Associated Mucin Glycopeptide

Trabbic KR, Whalen K, Abarca-Heideman K, Xia L, Temme JS, Edmondson EF, Gildersleeve JC, Barchi JJ Jr.
Sci Rep. 9(1): 5662, 2019. [ Journal Article ]

Synthetic ligands for PreQ1 riboswitches provide structural and mechanistic insights into targeting RNA tertiary structure

Connelly CM, Numata T, Boer RE, Moon MH, Sinniah RS, Barchi JJ, Ferré-D'Amaré AR, Schneekloth JS Jr.
Nat Commun.. 10(1): 1501, 2019. [ Journal Article ]

Endothelial Integrin α3β1 Stabilizes Carbohydrate-Mediated Tumor/Endothelial Cell Adhesion and Induces Major Signaling Pathways in Endothelial Cells

Glinskii OV, Li F, Wilson LS, Barnes S, Rittenhouse-Olson K, Barchi Jr JJ, Pienta KJ, Glinsky VV
Oncotarget. 5: 1382-1389, 2014. [ Journal Article ]

Recognition of the Thomsen-Friedenreich pancarcinoma carbohydrate antigen by a lamprey variable lymphocyte receptor

Luo M, Velikovsky CA, Yang X, Siddiqui MA, Hong X, Barchi JJ, Gildersleeve JC, Pancer Z, Mariuzza RA.
J. Biol. Chem. 288: 23597-23606, 2013. [ Journal Article ]

Mucin-type glycopeptide structure in solution: Past, present, and future

Barchi Jr JJ
Biopolymers. 99: 713-723, 2013. [ Journal Article ]

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Kavita Belligund, Ph.D.
Postdoctoral Fellow (Visiting)
Utpal Kumar Mondal, Ph.D.
Caitlin Strain, B.S.


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