Jonathan R. Keller, Ph.D.

Jonathan R. Keller, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Mouse Cancer Genetics Program


The balance between maintaining stem cells and their more differentiated progeny is critical for the development and function of most tissues. Understanding how stem cells self-renew and commit to specific cell lineages remains a central question in stem cell biology. The laboratory is currently focused on understanding the cellular and molecular regulation of hematopoietic stem cell (HSC) quiescence, survival, self-renewal, and cell fate. These processes are regulated, in part, by transcription factors and epigenetic regulators recruited to DNA, which modify histones, DNA, and other proteins to activate or repress gene expression. The laboratory is currently defining the physiological function of the inhibitor of DNA binding (Id) family of proteins in self-renewal, quiescence and cell fate determination. Since transcription factors and epigenetic regulators are frequently deregulated in hematopoietic malignancies, it is anticipated that these studies will lead to the development of novel therapeutic agents.

Areas of Expertise

Development And Stem Cells
Leukemia And Lymphoma
Molecular Regulation Of Self Renewal And Cell Fate
Blood And Bone Marrow Transplantation
Myeloid Malignancies


Selected Key Publications

Id1 Ablation Protects Hematopoietic Stem Cells from Stress-Induced Exhaustion and Aging.

Singh SK, Singh S, Gadomski S, Sun L, Pfannenstein A, Magidson V, Chen X, Kozlov S, Tessarollo L, Klarmann KD, Keller JR.
Cell Stem Cell. 252-265.e8. doi: 10.1016/j.stem.2018.06.001: 2018. [ Journal Article ]

POGZ Is Required for Silencing Mouse Embryonic β-like Hemoglobin and Human Fetal Hemoglobin Expression.

Gudmundsdottir B, Gudmundsson KO, Klarmann KD, Singh SK, Sun L, Singh S, Du Y, Coppola V, Stockwin L, Nguyen N, Tessarollo L, Thorsteinsson L, Sigurjonsson OE, Gudmundsson S, Rafnar T, Tisdale JF, Keller JR.
Cell Rep. 23(11):3236-3248. doi: 10.1016/j.celrep.2018.05.043.: 2018. [ Journal Article ]

Repression of Id2 expression by Gfi-1 is required for B-cell and myeloid development

Li H, Ji M, Klarmann KD, Keller JR
Blood. 116(7): 1060-9, 2010. [ Journal Article ]

Loss of Folliculin Disrupts Hematopoietic Stem Cell Quiescence and Homeostasis Resulting in Bone Marrow Failure

Baba M, Toyama H, Sun L, Takubo K, Suh HC, Hasumi H, Nakamura-Ishizu A, Hasumi Y, Klarmann KD, Nakagata N, Schmidt LS, Linehan WM, Suda T, Keller JR.
Stem cells . 34(4): 1068-82, 2016. [ Journal Article ]

Id1 immortalizes hematopoietic progenitors in vitro and promotes a myeloproliferative disease in vivo

Suh HC, Leeanansaksiri W, Ji M, Klarmann KD, Renn K, Gooya J, Smith D, McNiece I, Lugthart S, Valk PJ, Delwel R, Keller JR
Oncogene. 27(42): 5612-23, 2008. [ Journal Article ]