Jeffrey N. Strathern, Ph.D.

Jeffrey N. Strathern, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
RNA Biology Laboratory


Two general areas of research were pursued in our section: mechanisms of genetic recombination and the fidelity of transcription. We focused on the area of genetic recombination in general and double-strand-break repair in particular. DNA palindromes are thought to be a common mechanism of gene amplification found in tumor cells. However, palindromes are particularly difficult to investigate because they are difficult to clone and difficult to sequence. We created yeast strains that tolerate DNA palindromes and developed a system in which they can be generated and we also developed a method to determine their sequence.

Areas of Expertise

Genetic Recombination
Gene Regulation