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Jeffrey C. Gildersleeve, Ph.D.

Jeffrey C. Gildersleeve, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Chemical Biology Laboratory

RESEARCH SUMMARY

The Gildersleeve group develops unique technologies and tools to research important but under studied problems at the intersection of cancer immunology and glycoscience. We use a variety of chemical and biological approaches to (1) understand how the immune system constructs glycan-binding antibodies, (2) investigate how endogenous glycan-binding antibodies contribute to human health, (3) develop new strategies to obtain and engineer glycan-binding antibodies with high affinity and selectivity, and (4) apply monoclonal antibodies to study glycobiology, especially as it relates to cancer. To facilitate these studies, we have a developed a glycan microarray, or carbohydrate antigen microarray, that allows high-throughput analysis of antibody binding properties and rapid profiling of glycan-binding antibody populations in serum.

Areas of Expertise

1) glycan array technology 2) anti-glycan antibodies 3) cancer vaccines 4) carbohydrate recognition 5) synthesis of carbohydrate antigens

Publications

Selected Recent Publications

Selective Recognition of Carbohydrate Antigens by Germline Antibodies Isolated from AID Knockout Mice

Andrew T. DeLaitsch, Jacey R. Pridgen, Avery Tytla, Megan L. Peach, Rayleen Hu, David W. Farnsworth, Aislinn K. McMillan, Natalie Flanagan, J. Sebastian Temme, Marc C. Nicklaus, and Jeffrey C. Gildersleeve*
Journal of the American Chemical Society. 144: 4925–4941, 2022.
Full-Text Article
[ Journal Article ]

Chemoenzymatic Synthesis of 9NHAc-GD2 Antigen to Overcome the Hydrolytic Instability of O-Acetylated-GD2 for Anticancer Conjugate Vaccine Development

Xuanjun Wu,Jinfeng Ye, Andrew T. DeLaitsch, Zahra Rashidijahanabad, Shuyao Lang, Tayeb Kakeshpour, Yuetao Zhao, Sherif Ramadan, Paulo Vilar Saavedra, Vilma Yuzbasiyan-Gurkan, Dr. Herbert Kavunja, Hongzhi Cao, Dr. Jeffrey C. Gildersleeve, Prof. Xuefei Huang
Angew Chem Int Ed Engl .. 60: 24179-24188, 2021.
Full-Text Article
[ Journal Article ]

Anti-glycan antibodies: roles in human disease

J. Sebastian Temme; Dorothy L. Butler; Jeffrey C. Gildersleeve
Biochem J.. 478: 1485–1509., 2021.
Full-Text Article

Therapeutic Antibodies to Ganglioside GD2 Evolved from Highly Selective Germline Antibodies

Sterner, E.; Peach, M.L.; Nicklaus, M.C.; Gildersleeve, J.C.
Cell Reports. 20/7: 1681-1691, 2017. [ Journal Article ]

Whole-Cell Cancer Vaccines Induce Large Antibody Responses to Carbohydrates and Glycoproteins

Xia, L.; Schrump, David, S.: Gildersleeve, J.C.
Cell Chemical Biology. 23/12: 1515-1525, 2016. [ Journal Article ]

Job Vacancies

There are no open positions at this time. Check back again later, or take a look at CCR's Careers page.

Team

Postbaccalaureate Fellow
Ivy Barrett, B.S.
Postbaccalaureate Fellow
Claire Brown, B.S.
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Research Chemist
David W. Farnsworth, M.S.
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Postbaccalaureate Fellow
Kara Gillmann, B.S.
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Postbaccalaureate Fellow
Samantha Marglous, B.S.
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Postdoctoral Fellow
Pavan Patel, Ph.D.
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Postdoctoral Fellow
J. Sebastian Temme, Ph.D.

Alumni

Alex Bahnick
Alex Bahnick
Postbaccalaureate Fellow (2019-2020)
Current Position: Ph.D. student, Duke University
Tiffany Bellomo
Tiffany Bellomo
Postbaccalaureatte Fellow (2016-2017)
Current Position: Clinical Fellow in Surgery, Massachusetts General Hospital, Harvard Medical School
Dorothy Butler, Ph.D.
Dorothy Butler, Ph.D.
Postdoctoral Fellow (2018-2021)
Current Position: Program Manager, American Cancer Society Action Network
Christopher Campbell, Ph.D.
Christopher Campbell, Ph.D.
Postdoctoral Fellow (2009-2012)
Current Position: Scientific Manager, MesoScale
Sudipa Chowdhury
Sudipa Chowdhury
Postbaccalaureate Fellow (2011-2013)
Current Position: Internal Medicine Residency, St. Michael's Medical Center
Molly Congdon, Ph.D.
Molly Congdon, Ph.D.
Postdoctoral Fellow (2016-2021)
Current Position: Scientist, National Center for Advancing Translational Sciences (NCATS)
Andy DeLaitsch
Andy DeLaitsch
Postbaccalaureate Fellow (2018-2019)
Current Position: Ph.D. student, Caltech
Sarah Durbin
Sarah Durbin
Postbaccalaureate Fellow (2015-2017)
Current Position: MD student, Baylor College of Medicine
Natalie Flanagan
Natalie Flanagan
Postbaccalaureatte Fellow (2015-2017)
Current Position: MD student, University of Maryland School of Medicine
Ruslan Gibadullin
Ruslan Gibadullin
Postbaccalaureate Fellow (2014-2016
Current Position: Ph.D. student, University of Wisconsin
Sean Llewellyn
Sean Llewellyn
Postbaccalaureate Fellow (2010-2011)
Current Position: Family Medicine Resident, University of Colorado Anschutz Medical Campus
Crystal Li
Crystal Li
Postbaccalaureate Fellow (2020-2021)
Current Position: MD student, University of Maryland School of Medicine
Qian Li, Ph.D.
Qian Li, Ph.D.
Postdoctoral Fellow (2007-2009)
Current Position: Director, McCormick
Zhitao Li, Ph.D.
Zhitao Li, Ph.D.
Postdoctoral Fellow (2003-2006)
Current Position: Research Chemist, Eastman Chemicals
Olaf Ludek, Ph.D.
Olaf Ludek, Ph.D.
Postdoctoral Fellow (2009-2010)
Current Position: Team Manager of the Quality Assessment Team, Icelandic Medicines Agency (IMA).
Joseph Manimala
Joseph Manimala
Postdoctoral Fellow (2004-2006)
Current Position: Associate Director, Biomarker Program, AbbVie
Aislinn McMillan
Aislinn McMillan
Postbaccalaureate Fellow (2017-2018)
Current Position: MD Student, University of California San Diego School of Medicine
Saddam Muthana, Ph.D.
Saddam Muthana, Ph.D.
Postdoctoral Fellow (2010-2014)
Current Position: Assistant Professor, Alfaisal University, Riyadh, Saudi Arabia
Oyinda Oyelaran, Ph.D.
Oyinda Oyelaran, Ph.D.
Postdoctoral Fellow (2006-2009)
Current Position: Professor and Associate Dean of Faculty for Faculty Affairs, Northeastern University
Jacey Pridgen
Jacey Pridgen
Postbaccalaureate Fellow (2020-2021)
Current Position: MD/PhD student, Baylor College of Medicine
Anthony Stapon, Ph.D.
Anthony Stapon, Ph.D.
Postdoctoral Fellow (2006-2007)
Tim Roach, Ph.D.
Tim Roach, Ph.D.
Postdoctoral Fellow (2003-2006)
Current Position: NBC Technical Advisor; Naval Special Warfare Development Group
Eric Sterner, Ph.D.
Eric Sterner, Ph.D.
Postdoctoral Fellow (2014-2018)
Current Position: Associate Principal Scientist, Merck
Avery Tytla
Avery Tytla
Postbaccalaureate Fellow (2019-2020)
Current Position: Ph.D. student, UC Berkeley
Shea Wright
Shea Wright
Postbaccalaureate Fellow (2013-2015)
Current Position: Neurology Residency, University of Utah
Lily Xia, Ph.D.
Lily Xia, Ph.D.
Postdoctoral Fellow (2013-2017)
Current Position: Associate Project Manager, Smithers - Pharmaceutical Development Services
Naomi Yamamoto
Naomi Yamamoto
Postbaccalaurete Fellow (2019-2020)
Current Position: MD/PhD student, University of Washington School of Medicine
Yalong Zhang, Ph.D.
Yalong Zhang, Ph.D.
Postdoctoral Fellow (2008-2013)
Current Position: Principal Scientist, Innovation and Commercial Development (ICD) at Tate & Lyle
Nick O'Brien
Nick O'Brien
Postbaccalaurete Fellow (2020-2022)
Current Position: MD/PhD student, Baylor College of Medicine