James B. Mitchell, Ph.D.

James B. Mitchell, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Mitchell’s primary research focus is identification of means to modify the radiation response of tumors and normal tissues. His research utilizes an array of agents to probe the radiosensitivity of cells/tissues including nitroxide-based antioxidants, chemical radiation protectors, and agents that target specific molecular pathways important in radiation responses. As Branch Chief, Dr. Mitchell manages translational research initiatives involving radiation modification, the influence of tumor microenvironment on cancer treatment, and novel molecular imaging platforms to assess tissue metabolism.

Areas of Expertise

1) radiation sensitization, 2) radiation protection, 3) redox processes, 4) oxidative stress,
5) nitroxide antioxidants, 6) chemoprevention


Selected Recent Publications

Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy

Oshima N, Ishida R, Kishimoto S, Beebe K, Brender JR, Yamamoto K, Urban D, Rai G, Johnson MS, Benavides G, Squadrito GL, Crooks D, Jackson J, Joshi A, Mott BT, Shrimp JH, Moses MA, Lee MJ, Yuno A, Lee TD, Hu X, Anderson T, Kusewitt D, Hathaway HH, Jadhav A, Picard D, Trepel JB, Mitchell JB, Stott GM, Moore W, Simeonov A, Sklar LA, Norenberg JP, Linehan WM, Maloney DJ, Dang CV, Waterson AG, Hall M, Darley-Usmar VM, Krishna MC, Neckers LM.
Cell Rep. 30(6): 1798-1810, 2020. [ Journal Article ]

Rationale for hypoxia assessment and amelioration for precision therapy and immunotherapy studies

Dewhirst MW, Mowery YM, Mitchell JB, Cherukuri MK, Secomb TW.
J Clin Invest. 129(2): 489-91, 2019. [ Journal Article ]

Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice

Matsumoto S, Kishimoto S, Saito K, Takakusagi Y, Munasinghe JP, Devasahayam N, Hart CP, Gillies RJ, Mitchell JB, Krishna MC.
Cancer Res. 78(14): 3783-92, 2018. [ Journal Article ]

Abemaciclib, a Selective CDK4/6 Inhibitor, Enhances the Radiosensitivity of Non-Small Cell Lung Cancer In Vitro and In Vivo

Naz S, Sowers A, Choudhuri R, Wissler M, Gamson J, Mathias A, Cook JA, Mitchell JB.
Clin Cancer Res. 24(16): 3994-4005, 2018. [ Journal Article ]

SMAC Mimetic Birinapant plus Radiation Eradicates Human Head and Neck Cancers with Genomic Amplifications of Cell Death Genes FADD and BIRC2

Eytan DF, Snow GE, Carlson S, Derakhshan A, Saleh A, Schiltz S, Cheng H, Mohan S, Cornelius S, Coupar J, Sowers AL, Hernandez L, Mitchell JB, Annunziata CM, Chen Z, Van Waes C.
Cancer Res. 76(18): 5442-54, 2016. [ Journal Article ]

Job Vacancies

There are no open positions at this time. Check back again later, or take a look at CCR's Careers page.


Rajani Choudhuri, Ph.D.
Staff Scientist
John A. Cook, Ph.D.
Janet W. Gamson
Program Staff
Lauren Gibson
Laboratory Technician (Contr)
Sangeeta Gohain
Askale Mathias, Ph.D.
Scientist (Volunteer)
Chandrasekhram Nagineni, Ph.D.
Postdoctoral Fellow
Sarwat Naz, Ph.D.
Biological Laboratory Technician
Anastasia L. Sowers