James B. Mitchell, Ph.D.

James B. Mitchell, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


Dr. Mitchell is a radiation biologist whose research focuses on evaluation of agents in combination with radiation that either enhances tumor sensitivity or protects normal tissues. He is interested in determining the mechanism of how such agents can alter radiation sensitivity.

Areas of Expertise

Radiation Sensitization
Radiation Protection
Redox Processes
Oxidative Stress


Selected Recent Publications

The antioxidant Tempol transforms gut microbiome to resist obesity in female C3H mice fed a high fat diet

Choudhuri R, Sowers AL, Chandramouli GVR, Gamson J, Krishna MC, Mitchell JB, Cook JA.
Free Radic Biol Med. 178: 380-390, 2022. [ Journal Article ]

PEGPH20, a PEGylated human hyaluronidase, induces radiosensitization by reoxygenation in pancreatic cancer xenografts. A molecular imaging study

Seki T, Saida Y, Kishimoto S, Lee J, Otowa Y, Yamamoto K, Chandramouli GV, Devasahayam N, Mitchell JB, Krishna MC, Brender JR.
Neoplasia. 30: 100793, 2022. [ Journal Article ]

Pharmacological inhibition of HSP90 radiosensitizes head and neck squamous cell carcinoma xenograft by inhibition of DNA damage repair, nucleotide metabolism, and radiation-induced tumor vasculogenesis

Naz S, Leiker AJ, Choudhuri R, Preston O, Sowers AL, Gohain S, Gamson J, Mathias A, Van Waes C, Cook JA, Mitchell JB.
Int J Radiat Oncol Biol Phys. 110(5): 1295-1305, 2021. [ Journal Article ]

Molecular imaging of the tumor microenvironment reveals the relationship between tumor oxygenation, glucose uptake and glycolysis in pancreatic ductal adenocarcinoma

Yamamoto K, Brender JR, Seki T, Kishmoto S, Oshima N, Choudhuri R, Adler SS, Jagoda E, Saito K, Devasahayam N, Choyke PL, Mitchell JB, Krishna MC.
Cancer Res. 80(11): 2087-2093, 2020. [ Journal Article ]

Abemaciclib, a Selective CDK4/6 Inhibitor Enhances the Radiosensitivity of Non-Small Cell Lung Cancer in vitro and in vivo

Naz S, Sowers AL, Choudhuri R, Wissler M, Gamson J, Mathias A, Cook JA, Mitchell JB.
Clin Cancer Res. 24(16): 3994-4005, 2018. [ Journal Article ]

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Rajani Choudhuri, Ph.D.
Staff Scientist
John A. Cook, Ph.D.
Janet W. Gamson
Laboratory Technician (Contr)
Sangeeta Gohain
Askale Mathias
Scientist (Volunteer)
Chandrasekhram Nagineni, Ph.D.
Postdoctoral Fellow
Sarwat Naz, Ph.D.
Program Specialist
Lindsey Shifflett
Biological Laboratory Technician
Anastasia L. Sowers


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