Jacek Lubkowski

Jacek Tadeusz Lubkowski, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Center for Structural Biology


Our current scientific interests focus primarily on investigating the structural basis of signaling by the cytokines that interact with class II receptors (i.e., IL-10, IFN-γ, etc.), aiming at structural characterization of their molecular components (cytokine, receptor, Janus kinase) and interactions. The ultimate goals of this research are to understand the details of signal transduction, specific to a particular cytokine-receptor-JAK system, and to correlate the structural properties of this system with its biological activity, paving a foundation for novel or improved therapeutic interventions targeting these signaling pathways. Although we primarily use x-ray crystallography in these studies, our research techniques also extend into biochemistry and molecular biology.

Areas of Expertise

Signal Transduction


Selected Publications

Crystal structure of XMRV protease differs from the structures of other retropepsins

Li M, Dimaio F, Zhou D, Gustchina A, Lubkowski J, Dauter Z, Baker D, Wlodawer A.
Nat. Struct. Mol. Biol.. 18: 227-9, 2011. [ Journal Article ]

Novel peptides based on HIV-1 gp120 sequence with homology to chemokines inhibit HIV infection in cell culture

Chertov O, Zhang N, Chen X, Oppenheim JJ, Lubkowski J, McGrath C, Sowder RC, Crise BJ, Malyguine A, Kutzler MA, Steele AD, Henderson EE, Rogers TJ.
PLoS ONE. 6: e14474, 2011. [ Journal Article ]

Preclinical evaluation of human secretoglobin 3A2 in mouse models of lung development and fibrosis

Cai Y, Winn ME, Zehmer JK, Gillette WK, Lubkowski JT, Pilon AL, Kimura S.
Am. J. Physiol. Lung Cell Mol. Physiol.. 306: L10-22, 2014. [ Journal Article ]

Human ß-defensin-3 structure motifs that are important in CXCR4 antagonism

Feng Z, Dubyak GR, Jia X, Lubkowski JT, Weinberg A.
FEBS J.. 280: 3365-75, 2013. [ Journal Article ]