Ilya Senatorov

Ilya Senatorov, Pharm.D, Ph.D

  • Center for Cancer Research
  • National Cancer Institute
Genitourinary Malignancies Branch


Dr. Senatorov is a cancer pharmacologist interested in deciphering therapy sensitivity and resistance profiles in prostate cancer across a broad compound library spanning many mechanistic classes. His current research combines high throughput compound screening with transcriptomic analysis for biomarker discovery and generation of prognostic gene signatures predicting response or resistance using patient-derived organoid models.

Areas of Expertise

Drug Mechanisms Of Action And Resistance
Organoid Culturing
Genomic And Transcriptomic Analysis
Gene Signatures


Selected Recent Publications

Novel and Highly Potent ATR Inhibitor M4344 Kills Cancer Cells With Replication Stress, and Enhances the Chemotherapeutic Activity of Widely Used DNA Damaging Agents

Jo U, Senatorov IS, Zimmermann A, Saha LK, Murai Y, Kim SH, Rajapakse VN, Elloumi F, Takahashi N, Schultz CW, Thomas A, Zenke FT, Pommier Y.
Mol Cancer Ther. May 27.10.1158/1535-7163: 2021. [ Journal Article ]

Carboxy-Terminal Phosphoregulation of the Long Splice Isoform of Free-Fatty Acid Receptor-4 Mediates β-Arrestin Recruitment and Signaling to ERK1/2

Senatorov IS, Cheshmehkani A, Burns RN, Singh K, Moniri NH.
Mol Pharmacol. May;97(5):304-313.: 2020. [ Journal Article ]

The role of free-fatty acid receptor-4 (FFA4) in human cancers and cancer cell lines

Senatorov IS, Moniri NH.
Biochem Pharmacol. Apr;150:170-180: 2018. [ Journal Article ]

Free-fatty acid receptor-4 (FFA4) modulates ROS generation and COX-2 expression via the C-terminal β-arrestin phosphosensor in Raw 264.7 macrophages

Cheshmehkani A, Senatorov IS, Dhuguru J, Ghoneim O, Moniri NH.
Biochem Pharmacol. Dec 15;146:139-150.: 2017. [ Journal Article ]

Fish oil and flax seed oil supplemented diets increase FFAR4 expression in the rat colon

Cheshmehkani A, Senatorov IS, Kandi P, Singh M, Britt A, Hayslett R, Moniri NH.
Inflamm Res. Oct;64(10):809-815, 2015. [ Journal Article ]