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Huaitian Liu

Huaitian Liu, Ph.D., M.S.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Liu develops biostatistical and bioinformatic approaches for the analysis of large-scale biomedical, epidemiological data as well as ‘omics data (WGS, WES, single-cell RNA-seq, single-cell ATAC-seq, spatial transcriptomics, RNA-seq, miRNA-seq and ChIP-seq). 

Areas of Expertise

1) cancer genomics and genetics 2) data science and computational biology 3) epidemiology 4) antibody engineering by phage display 5) bioinformatics tool development

Publications

Selected Key Publications

Chromatin Accessibility Landscape of Human Triple-negative Breast Cancer Cell Lines Reveals Variation by Patient Donor Ancestry

Harris AR*, Panigrahi G*, Liu H*, Koparde VN, Bailey-Whyte M, Dorsey TH, Yates CC, Ambs S.
Cancer Res Commun. Oct 5;3(10): 2014-2029, 2023. [ Journal Article ]

SERPINB3-MYC axis induces the basal-like/squamous subtype and enhances disease progression in pancreatic cancer

Ohara Y, Tang W, Liu H, Yang S, Dorsey TH, Cawley H, Moreno P, Chari R, Guest MR, Azizian A, Gaedcke J, Ghadimi M, Hanna N, Ambs S, Hussain SP.
Cell Rep. 42(12): 113434, 2023. [ Journal Article ]

Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response

Amin R, Shukla A, Zhu JJ, Kim S, Wang P, Tian SZ, Tran AD, Paul D, Cappell SD, Burkett S, Liu H, Lee MP, Kruhlak MJ, Dwyer JE, Simpson RM, Hager GL, Ruan Y, Hunter KW.
Nat Commun. 12(1): 7216, 2021. [ Journal Article ]

Genomic Landscape of Somatic Alterations in Esophageal Squamous Cell Carcinoma and Gastric Cancer

Hu N, Kadota M, Liu H, Abnet CC, Su H, Wu H, Freedman ND, Yang HH, Wang C, Yan C, Wang L, Gere S, Hutchinson A, Song G, Wang Y, Ding T, Qiao YL, Koshiol J, Dawsey SM, Giffen C, Goldstein AM, Taylor PR, Lee MP.
Cancer Res. 76(7): 1714-23, 2016. [ Journal Article ]

Reciprocal effects of C/EBPalpha and PKCdelta on JunB expression and monocytic differentiation depend upon the C/EBPalpha basic region

Liu H, Keefer JR, Wang QF, Friedman AD.
Blood. 101(10): 3885-92, 2003. [ Journal Article ]