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Hans Elmlund

Hans Elmlund, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Senior Investigator
Center for Structural Biology
Head, Biological Computing Section

RESEARCH SUMMARY

Hans Elmlund is an internationally renowned electron microscopist who pioneered the use of stochastic 3D reconstruction algorithms for analyzing images obtained with cryo-electron microscopy and graphene-liquid-cell electron microscopy. His laboratory develops novel algorithmic solutions to address the most difficult problems in areas ranging from structural biology to nanoscience.

Areas of Expertise

Cryo-Electron Microscopy
Liquid-Cell Electron Microscopy
Integrative Structural Biology
Image Processing

Publications

Selected Publications

SINGLE: Atomic-resolution structure identification of nanocrystals by graphene liquid cell EM

Reboul CF, Heo J, Machello C, Kiesewetter S, Kim BH, Kim S, Elmlund D, Ercius P, Park J, Elmlund H.
Sci Adv. Jan 29;7(5): eabe6679, 2021. [ Journal Article ]

SIMPLE 3.0. Stream single-particle cryo-EM analysis in real time

Caesar J, Reboul CF, Machello C, Kiesewetter S, Tang ML, Deme JC, Johnson S, Elmlund D, Lea SM, Elmlund H.
J Struct Biol X. Nov 7;4: 100040, 2020. [ Journal Article ]

Critical differences in 3D atomic structure of individual ligand-protected nanocrystals in solution

Kim BH, Heo J, Kim S, Reboul CF, Chun H, Kang D, Bae H, Hyun H, Lim J, Lee H, Han B, Hyeon T, Alivisatos AP, Ercius P, Elmlund H, Park J.
Science. Apr 3;368(6486):: 60-67, 2020. [ Journal Article ]

Rapid near-atomic resolution single-particle 3D reconstruction with SIMPLE

Reboul CF, Kiesewetter S, Eager M, Belousoff M, Cui T, De Sterck H, Elmlund D, Elmlund H.
J Struct Biol. Nov;204(2): 172-181, 2018. [ Journal Article ]

A Stochastic Hill Climbing Approach for Simultaneous 2D Alignment and Clustering of Cryogenic Electron Microscopy Images

Reboul CF, Bonnet F, Elmlund D, Elmlund H.
Structure. Jun 7;24(6): 988-96, 2016. [ Journal Article ]

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Team

Photo of NCI-CCR-CSB-BCS team Member Cyril Reboul
STAFF SCIENTIST
Cyril Reboul, Ph.D.
STAFF SCIENTIST
Ruben Meana Paneda, Ph.D.
Photo of NCI-CCR-CSB-BCS Team Member Cong Tuan Son Van
Research Fellow
Cong Tuan Son Van, Ph.D.
Predoctoral Fellow
Canran Ji

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