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Euna Yoo, Ph.D.

Euna Yoo, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
  • Building 538, Room 246
  • Frederick, MD, 21702-1201
  • 301-228-4546
  • euna.yoo@nih.gov
Chemical Biology Laboratory

RESEARCH SUMMARY

Our goal is to discover novel chemical approaches and molecules that can address immunological problems in cancer therapy. Our research applies and advances chemical proteomics to develop new strategies to study and manipulate the human immune system. We use natural product screening and synthetic chemistry to develop chemical probes that specifically detect and perturb key regulators of biochemical and signaling pathways and functional enzymes involved in immune activation and tolerance.

Areas of Expertise

1) organic chemistry 2) chemical immunology 3) chemical proteomics 4) biochemistry 5) drug discovery

Publications

Selected Recent Publications

The Antimalarial Natural Product Salinipostin A Identifies Essential α/β Serine Hydrolases Involved in Lipid Metabolism in P. falciparum Parasites

Yoo E, Schulze CJ, Stokes BH, Onguka O, Yeo T, Mok S, Gnädig NF, Zhou Y, Kurita K, Foe IT, Terrell SM, Boucher MJ, Cieplak P, Kumpornsin K, Lee MCS, Linington RG, Long JZ, Uhlemann AC, Weerapana E, Fidock DA, Bogyo M
Cell Chem Biol. 27: 1-15, 2020. [ Journal Article ]

Defining the Determinants of Specificity of Plasmodium Proteasome Inhibitors

Yoo E, Stokes BH, de Jong H, Vanaerschot M, Kumar T, Lawrence N, Njoroge M, Garcia A, Van der Westhuyzen R, Momper JD, Ng CL, Fidock DA, Bogyo M.
J Am Chem Soc. 140: 11424-11437, 2018. [ Journal Article ]

Hyaluronic Acid Conjugates of TLR7/8 Agonists for Targeted Delivery to Secondary Lymphoid Tissue

Yoo E, Salyer ACD, Brush MJH, Li Y, Trautman KL, Shukla NM, De Beuckelaer A, Lienenklaus S, Deswarte K, Lambrecht BN, De Geest BG, David SA.
Bioconjug Chem. 29: 2741-2754, 2018. [ Journal Article ]

Structure- and function-based design of Plasmodium-selective proteasome inhibitors

Li H, O'Donoghue AJ, van der Linden WA, Xie SC, Yoo E, Foe IT, Tilley L, Craik CS, da Fonseca PC, Bogyo M.
Nature. 530: 233-236, 2016. [ Journal Article ]

Determinants of activity at human Toll-like receptors 7 and 8: quantitative structure-activity relationship (QSAR) of diverse heterocyclic scaffolds

Yoo E, Salunke DB, Sil D, Guo X, Salyer AC, Hermanson AR, Kumar M, Malladi SS, Balakrishna R, Thompson WH, Tanji H, Ohto U, Shimizu T, David SA.
J Med Chem. 57: 7955-7970, 2015. [ Journal Article ]

Job Vacancies

Position Degree Required Contact Name Contact Email
Post-doctoral Fellow - Chemical immunology, protease biology Ph.D. or equivalent Euna Yoo euna.yoo@nih.gov

Team

Postbaccalaureate Fellow (CRTA)
David P. Byun
Postdoctoral Fellow (Visiting)
Arghya Ganguly , Ph.D.
Postbaccalaureate Fellow (CRTA)
Samantha Ono
Postdoctoral Fellow (Visiting)
Ravichandra Tagirasa , Ph.D.
Postbaccalaureate Fellow (CRTA)
Jennifer Ritchie

Alumni

Anthony Omole
Anthony Omole
2020-2021
Postbaccalaureate Fellow (CRTA)
Hong-Rae Kim, Ph.D.
Hong-Rae Kim, Ph.D.
2020-2022
Postdoctoral Fellow (Visiting)