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Drew Pratt

Drew W. Pratt, M.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Pathology

RESEARCH SUMMARY

Dr. Pratt’s laboratory seeks to use multi-omic (epi)genomic data, including DNA methylation profiling and DNA/RNA-seq, to refine the classification of cancer and to discover novel, clinically-relevant entities. This will ultimately lead to improved diagnostic precision and prognostication for patients.

Areas of Expertise

1) brain tumor pathology, 2) cancer genomics and epigenomics, 3) bioinformatics, 4) machine learning

Publications

Selected Key Publications

A novel ATXN1-DUX4 fusion expands the spectrum of 'CIC-rearranged sarcoma' of the CNS to include non-CIC alterations

Pratt D, Kumar-Sinha C, Cieślik M, Mehra R, Xiao H, Shao L, Franson A, Cantor E, Chinnaiyan AM, Mody R, Abdullaev Z, Aldape K, Quezado M, Camelo-Piragua S.
Acta Neuropathol. 141(4): 619-622, 2021. [ Journal Article ]

Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas

Chung C, Sweha SR, Pratt D, Tamrazi B, Panwalkar P, Banda A, Bayliss J, Hawes D, Yang F, Lee HJ, Shan M, Cieslik M, Qin T, Werner CK, Wahl DR, Lyssiotis CA, Bian Z, Shotwell JB, Yadav VN, Koschmann C, Chinnaiyan AM, Blüml S, Judkins AR, Venneti S.
Cancer Cell. 38(3): 334-349.e9, 2020. [ Journal Article ]

SWI/SNF complex heterogeneity is related to polyphenotypic differentiation, prognosis, and immune response in rhabdoid tumors

Panwalkar P, Pratt D, Chung C, Dang D, Le P, Martinez D, Bayliss JM, Smith KS, Adam M, Potter S, Northcott PA, Mascarenhas L, Shows J, Pawel B, Margol A, Huang A, Judkins AR, Venneti S.
Neuro Oncol. 22(6): 785-796, 2020. [ Journal Article ]

BRAF activating mutations involving the β3-αC loop in V600E-negative anaplastic pleomorphic xanthoastrocytoma

Pratt D, Camelo-Piragua S, McFadden K, Leung D, Mody R, Chinnaiyan A, Koschmann C, Venneti S.
Acta Neuropathol Commun. 6(1): 24, 2018. [ Journal Article ]

Circumscribed/non-diffuse histology confers a better prognosis in H3K27M-mutant gliomas

Pratt D, Natarajan SK, Banda A, Giannini C, Vats P, Koschmann C, Mody R, Chinnaiyan A, Venneti S.
Acta Neuropathol. 135(2): 299-301, 2018. [ Journal Article ]

Job Vacancies

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