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Dinah S. Singer, Ph.D.

Dinah S. Singer, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Experimental Immunology Branch

RESEARCH SUMMARY

Dr. Singer’s research has provided novel insights into the molecular mechanisms that regulate MHC class I transcription in vivo. Her most recent studies have identified 1) the mitotic bookmark, BRD4, as a novel kinase that regulates early transcription, linking mitosis and transcription and 2) the transcription factor, TAF7, as a checkpoint regulator of early transcription.

Dr. Singer's research program is focused on interrogating the regulatory networks governing transcription to generate an integrated understanding of the interplay between promoter elements and transcription complexes that establish appropriate regulation of gene expression across diverse cellular and tissue environments.

Areas of Expertise

1) molecular biology, 2) immunology, 3) gene expression, 4) biochemistry, 5) animal models

Publications

Selected Recent Publications

MYC protein stability is negatively regulated by BRD4

Devaiah BN, Mu J, Akman B, Uppal S, Weissman JD, Cheng D, Baranello L, Nie Z, Levens D, Singer DS.
Proc Natl Acad Sci USA. [Epub ahead of print], 2020. [ Journal Article ]

The Bromodomain Protein 4 Contributes to the Regulation of Alternative Splicing

Uppal S, Gegonne A, Chen Q, Thompson PS, Cheng D, Mu J, Meerzaman D, Misra HS, Singer DS.
Cell Rep. 29(8): 2450-60, 2019. [ Journal Article ]

Immature CD8 Single-Positive Thymocytes Are a Molecularly Distinct Subpopulation, Selectively Dependent on BRD4 for Their Differentiation

Gegonne A, Chen QR, Dey A, Etzensperger R, Tai X, Singer A, Meerzaman D, Ozato K, Singer DS.
Cell Rep. 24(1): 117-29, 2018. [ Journal Article ]

Implementing the Cancer Moonshot and beyond

Lowy DR, Singer DS.
Lancet Oncol. 18(11): e622-e623, 2017. [ Journal Article ]

BRD4 is a histone acetyltransferase that evicts nucleosomes from chromatin

Devaiah BN, Case-Borden C, Gegonne A, Hsu CH, Chen Q, Meerzaman D, Dey A, Ozato K, Singer DS.
Nat Struct Mol Biol. 23(6): 540-8, 2016. [ Journal Article ]

Job Vacancies

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Team

Staff Scientist
Devaiah Ballachanda, Ph.D.
Postdoctoral Fellow (CRTA)
Dan Cheng, Ph.D.
Biologist (Contr.)
Aparna Kotekar, Ph.D.
Postbaccalaureate Fellow (CRTA)
Elizabeth McManus
Biologist
Jie Mu, Ph.D.
Postdoctoral Fellow (Visiting)
Amit Singh, Ph.D.
Postbaccalaureate Fellow (CRTA)
Tamia Waller
Chemist
Jocelyn Weissman