Breadcrumb

Diana A. Stavreva, Ph.D.

Diana A. Stavreva, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

I began my scientific career in the field of environmental mutagenesis. My work on DNA damage and repair at the single cell level motivated me to further explore single cell biology. I have been working on the development and implementation of a high-throughput, automated, cell-based screening protocol for the detection of biologically active endocrine-disrupting chemicals (EDCs) in environmental samples. Considering that exposure to EDCs has many deleterious effects, including abnormal breast development as well as an increased incidence of prostate and thyroid cancers, the efficient screening and elimination of EDCs from the environment could substantially reduce the risk of these ailments.

Areas of Expertise

1) transcription regulation, 2) chromatin dynamics, 3) nuclear receptor biology, 4) endocrine disrupting chemicals, 5) imaging, 6) genomics

Publications

Selected Publications

Pilot study of global endocrine disrupting activity in Iowa public drinking water utilities using cell-based assays

Jones RR, Stavreva DA, Weyer PJ, Varticovski L, Inoue-Choi M, Medgyesi DN, Chavis N, Graubard BI, Cain T, Wichman M, Beane Freeman LE, Hager GL, Ward MH5
Science of The Total Environment. 714: 2020. [ Journal Article ]

Transcriptional Bursting and Co-bursting Regulation by Steroid Hormone Release Pattern and Transcription Factor Mobility

Stavreva DA, Garcia DA, Fettweis G, Gudla PR, Zaki GF, Soni V, McGowan A, Williams G, Huynh A, Palangat M, Schiltz RL, Johnson TA, Presman DM, Ferguson ML, Pegoraro G, Upadhyaya A, Hager GL
Molecular Cell. 75(6): 1161-1177, 2019. [ Journal Article ]

Novel cell-based assay for detection of thyroid receptor beta-interacting environmental contaminants

Stavreva DA, Varticovski L, Levkova L, George AA. Davis L, Pegoraro G, Blazer V, Iwanowicz L, Hager GL
Toxicology. 368-369: 69-79, 2016. [ Journal Article ]

Dynamics of chromatin accessibility and long-range interactions in response to glucocorticoid pulsing

Stavreva DA, Coulon A, Baek S, Sung MH, John S, Stixova L, Tesikova M, Hakim O, Miranda T, Hawkins M, Stamatoyannopoulos JA, Chow CC, Hager GL
Genome Research. 25(6): 845-857, 2015. [ Journal Article ]

Ultradian hormone stimulation induces glucocorticoid receptor-mediated pulses of gene transcription

Stavreva DA, Wiench M, John S, Conway-Campbell BL, McKenna MA, Pooley JR, Johnson TA, Voss TC, Lightman SL, Hager GL.
Nat. Cell Biol.. 11: 1093-102, 2009. [ Journal Article ]