DeeDee K. Smart, M.D., Ph.D.

DeeDee K. Smart, M.D., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute


The Smart lab aims to define molecular pathways that lead to neurodegeneration and functional neuropsychological changes in response to CNS treatment with ionizing radiation as well as determine the molecular mechanisms that regulate the radiation response and radioresistance of brain metastases in order to improve current available therapies so that curative treatment is possible.

Clinically, Dr. Smart oversees clinical trials to identify biomarkers related to radiation induced neuropsychological changes and normal tissue injury, long-term surveillance of patients who receive radiotherapy for breast cancer, and radiotherapy of malignant and non-malignant brain tumors.

Areas of Expertise

Brain Metastasis
Radiation-Induced Neurodegeneration

Information for Patients

Learn more about our clinical trials and the highly specialized care teams that lead them. 


Selected Publications

Radiation-induced astrocyte senescence is rescued by Δ133p53

Turnquist C, Beck JA, Horikawa I, Obiorah IE, Von Muhlinen N, Vojtesek B, Lane DP, Grunseich C, Chahine JJ, Ames HM, Smart DD, Harris BT, Harris CC.
Neuro Oncol. 21(4): 474-85, 2019. [ Journal Article ]

Temozolomide in secondary prevention of HER2-positive breast cancer brain metastases

Zimmer AS, Steinberg SM, Smart DD, Gilbert MR, Armstrong TS, Burton E, Houston N, Biassou N, Gril B, Brastianos PK, Carter S, Lyden D, Lipkowitz S, Steeg PS.
Future Oncol. 16(14): 899-909, 2020. [ Journal Article ]

Radiation chronotherapy-clinical impact of treatment time-of-day: a systematic review

Shuboni-Mulligan DD, Breton G, Smart D, Gilbert M, Armstrong TS.
J Neurooncol. 145(3): 415-27, 2019. [ Journal Article ]

Differentiating pseudoprogression from true progression: analysis of radiographic, biologic, and clinical clues in GBM

Rowe LS, Butman JA, Mackey M, Shih JH, Cooley-Zgela T, Ning H, Gilbert MR, Smart DK, Camphausen K, Krauze AV.
J Neurooncol. 139(1): 145-52, 2018. [ Journal Article ]

Re-irradiation for recurrent glioma- the NCI experience in tumor control, OAR toxicity and proposal of a novel prognostic scoring system

Krauze AV, Peters C, Cheng J, Ning H, Mackey M, Rowe L, Cooley-Zgela T, Smart DD, Camphausen K.
Radiat Oncol. 12(1): 191, 2017. [ Journal Article ]

Job Vacancies

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Research Biologist
Alexandra Lin, Ph.D.
Postdoctoral Fellow (Visiting)
Nihar Mehta, Ph.D.
Postbaccalaureate Fellow (CRTA)
Hari Nath
Postbaccalaureate Fellow
Diane Rhee


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