National Cancer Institute - Cancer.gov

Daxeshkumar P. Patel, Ph.D.

Daxeshkumar P. Patel, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Staff Scientist
Laboratory of Human Carcinogenesis

RESEARCH SUMMARY

Daxeshkumar P. Patel, Ph.D., is a Staff Scientist at the National Cancer Institute (NCI), NIH, specializing in computational biology, analytical chemistry, and multiomics research. He employs advanced mass spectrometry and machine learning to investigate biomarkers such as creatine riboside and 561.3+m/z, uncovering molecular mechanisms in liver and lung cancers. His work focuses on pathway analyses, novel biomarker characterization, and precision medicine strategies, driving innovations in early cancer diagnostics and therapeutic development for metabolic disorders. Dr. Patel’s expertise bridges molecular biology and bioinformatics, advancing the frontiers of cancer research and personalized medicine.

Areas of Expertise

Molecular Mechanisms of Cancer
Cancer Metabolism
Diagnostics and Biomarkers
Precision Medicine
Computational Biology
Epidemiology

Publications

Selected Key Publications

Associations of chronic liver disease and liver cancer with glyphosate and its metabolites in Thailand

Daxesh P Patel, Christopher A Loffredo, Benjarath Pupacdi, Siritida Rabibhadana, Panida Navasumrit, Jittiporn Chaisaingmongkol, Leila Toulabi, Majda Haznadar, Bhavik Dalal, Mohammed Khan, Joshua Stone, Vajarabhongsa Bhudhisawasdi, Nirush Lertprasertsuke, Anon Chotirosniramit, Chawalit Pairojkul, Chirayu U Auewarakul, Thaniya Sricharunrat, Kannika Phornphutkul, Suleeporn Sangrajrang, Anuradha Budhu, Chulabhorn Mahidol, Xin W Wang, Frank J Gonzalez, Mathuros Ruchirawat, Curtis C Harris, TIGER‐LC Consortium
Int J Cancer. 1-13, 2024. [ Journal Article ]

Intestinal peroxisome proliferator-activated receptor α-fatty acid-binding protein 1 axis modulates nonalcoholic steatohepatitis

Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W Krausz, Daxesh P Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J Gonzalez

Hepatology. 1;77(1): 239-255, 2023. [ Journal Article ]

Creatine riboside is a cancer cell-derived metabolite associated with arginine auxotrophy

Amelia L Parker, Leila Toulabi, Takahiro Oike, Yasuyuki Kanke, Daxeshkumar Patel, Takeshi Tada, Sheryse Taylor, Jessica A Beck, Elise Bowman, Michelle L Reyzer, Donna Butcher , Skyler Kuhn, Gary T Pauly, Kristopher W Krausz, Frank J Gonzalez, S Perwez Hussain, Stefan Ambs, Bríd M Ryan, Xin Wei Wang, Curtis C Harris
J Clin Invest. 15;132(14): e157410, 2022. [ Journal Article ]

Withaferin A Improves Nonalcoholic Steatohepatitis in Mice

Daxesh P Patel, Tingting Yan, Donghwan Kim, Henrique B Dias, Kristopher W Krausz, Shioko Kimura, Frank J Gonzalez
J Pharmacol Exp Ther.. 371(2): 360-374, 2019. [ Journal Article ]

Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota

Guolin Li, Cen Xie, Siyu Lu, Robert G Nichols, Yuan Tian, Licen Li, Daxeshkumar Patel, Yinyan Ma, Chad N Brocker, Tingting Yan, Kristopher W Krausz, Rong Xiang, Oksana Gavrilova, Andrew D Patterson, Frank J Gonzalez
Cell Metab.. 26(4): 672-685, 2017. [ Journal Article ]