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David S. Salomon, Ph.D.

David S. Salomon, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Mouse Cancer Genetics Program

RESEARCH SUMMARY

The embryonic cell surface signaling protein, Cripto-1, is re-expressed at a high frequency in a number of different cancers, including non-small cell lung carcinomas (NSLC). Dr. Salomon helped to develop a toxin-conjugated humanized monoclonal antibody (Mab) against Cripto-1 as an initial step in developing a targeted therapeutic for NSLC patients. This Mab (BIIB015) was then evaluated for therapeutic efficacy in a Phase II clinical trial. Dr. Salomon was involved in the initial discovery of the mouse and human Cripto-1 genes and in the characterization of the biological activities associated with this family of proteins that function as co-receptors and chaperones for different embryonic signaling pathways such as Nodal, Wnt and Notch, which are essential in the generation and maintenance of embryonic and cancer stem cells.

Areas of Expertise

1) breast cancer 2) cell signaling 3) stem cells 4) mammary gland development 5) embryonic development 6) small molecule inhibitors

Publications

Selected Recent Publications

Breast and Colon Carcinomas: Detection with Plasma Levels of Cripto-1

Bianco C, Strizzi L, De Luca A, Normanno N and Salomon DS. Hayat MA (ed.)
Vol. 1: Breast Carcinoma: Chapter 15: 189-202, 2008. [ Book Chapter ]

Regulation of human Cripto-1 expression by nuclear receptors and DNA promoter methylation in human embryonal and breast cancer cells

Bianco C, Castro NP, Baraty C, Rollman K, Held N, Rangel RC, Karasawa H, Gonzales M, Strizzi L, and Salomon DS
J Cell Physiol. 228: 1174-83, 2013. [ Journal Article ]

Embryonic stem cells are redirected to non-tumorigenic epithelial cell fate by interaction with the mammary microenvironment

Boulanger C, Bruno RD, Gonzales M, Salomon DS, Castro N, Mack D and Smith GH
PLoS One. 8: e62019, 2013. [ Journal Article ]

SCNH2 is a novel apelinergic family member acting as a potent mitogenic and chemotactic factor for both endothelial and epithelial cells

Fan C, Avis I, Bianco C Held N, Morris J, Ylaya K, Hewitt SM, Aplin AC, Nicosia RF, Fung LA, Lewis JD, Stetler-Stevenson WG, Salomon DS and Cuttitta F
Open J Clin Diagn. 3: 37-51, 2013. [ Journal Article ]

Identification of caveolin-1 as a potential causative factor in the generation of trastuzmab resistance in breast cancer cells

Sekhar SC, Kasai T, Satoh A, Shigehiro T, Mizutani A, Murakami H, El-Aarag BYA, Salomon DS, Massaguer A, Liorens R, and Seno M
J Cancer. 4: 391-401, 2013. [ Journal Article ]