David FitzGerald, Ph.D.

David J. FitzGerald, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Molecular Biology


The Biotherapy Section develops therapeutic antibodies for treating cancer, especially antibody-drug conjugates.  Currently, we target the Epidermal Growth Factor Receptor on cancer cells.  We also explore cell death pathways.

Areas of Expertise

Cancer Therapeutics
Cell Biology


Selected Key Publications

Minimal residual hairy cell leukemia eradication with moxetumomab pasudotox: phase 1 results and long-term follow-up

Kreitman RJ, Tallman MS, Robak T, Coutre S, Wilson WH, Stetler-Stevenson M, FitzGerald DJ, Santiago L, Gao G, Lanasa MC, Pastan I
Blood. 131(21): 2331-34, 2018. [ Journal Article ]

Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity

Pasetto M, Antignani A, Ormanoglu P, Buehler E, Guha R, Pastan I, Martin SE, FitzGerald DJ
Proc Natl Acad Sci U S A. 112(10): E1135-42, 2015. [ Journal Article ]

Chemical Screens Identify Drugs that Enhance or Mitigate Cellular Responses to Antibody-Toxin Fusion Proteins

Antignani A, Mathews Griner L, Guha R, Simon N, Pasetto M, Keller J, Huang M, Angelus E, Pastan I, Ferrer M, FitzGerald DJ, Thomas CJ
PLoS One. 11(8): e0161415, 2016. [ Journal Article ]

Tofacitinib suppresses antibody responses to protein therapeutics in murine hosts

Onda M, Ghoreschi K, Steward-Tharp S, Thomas C, O'Shea JJ, Pastan IH, FitzGerald DJ
J Immunol. 193(1): 48-55, 2014. [ Journal Article ]

ABT-737 promotes the dislocation of ER luminal proteins to the cytosol, including Pseudomonas exotoxin

Antignani A, Sarnovsky R, Fitzgerald DJ.
Mol. Cancer Ther. 13: 1655-63, 2014. [ Journal Article ]

Job Vacancies

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Staff Scientist
Antonella Antignani, Ph.D.
Research Biologist
Robert Sarnovsky
Postbaccalaureate Fellow
Angel Obiorah
Postdoctoral Fellow (Visiting)
Suman Sourabh, Ph.D.