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David FitzGerald, Ph.D.

David J. FitzGerald, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Molecular Biology

RESEARCH SUMMARY

The Biotherapy Section develops therapeutic antibodies for treating cancer, especially antibody-drug conjugates.  Currently, we target the Epidermal Growth Factor Receptor on cancer cells.  We also explore cell death pathways.

Areas of Expertise

Antibodies
Immunotoxins
Cancer Therapeutics
Cell Biology

Publications

Selected Key Publications

Minimal residual hairy cell leukemia eradication with moxetumomab pasudotox: phase 1 results and long-term follow-up

Kreitman RJ, Tallman MS, Robak T, Coutre S, Wilson WH, Stetler-Stevenson M, FitzGerald DJ, Santiago L, Gao G, Lanasa MC, Pastan I
Blood. 131(21): 2331-34, 2018. [ Journal Article ]

Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity

Pasetto M, Antignani A, Ormanoglu P, Buehler E, Guha R, Pastan I, Martin SE, FitzGerald DJ
Proc Natl Acad Sci U S A. 112(10): E1135-42, 2015. [ Journal Article ]

Chemical Screens Identify Drugs that Enhance or Mitigate Cellular Responses to Antibody-Toxin Fusion Proteins

Antignani A, Mathews Griner L, Guha R, Simon N, Pasetto M, Keller J, Huang M, Angelus E, Pastan I, Ferrer M, FitzGerald DJ, Thomas CJ
PLoS One. 11(8): e0161415, 2016. [ Journal Article ]

Tofacitinib suppresses antibody responses to protein therapeutics in murine hosts

Onda M, Ghoreschi K, Steward-Tharp S, Thomas C, O'Shea JJ, Pastan IH, FitzGerald DJ
J Immunol. 193(1): 48-55, 2014. [ Journal Article ]

ABT-737 promotes the dislocation of ER luminal proteins to the cytosol, including Pseudomonas exotoxin

Antignani A, Sarnovsky R, Fitzgerald DJ.
Mol. Cancer Ther. 13: 1655-63, 2014. [ Journal Article ]

Job Vacancies

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Team

Staff Scientist
Antonella Antignani, Ph.D.
Postdoctoral Fellow (Visiting)
Maria Bilotta, Ph.D.
Postdoctoral Fellow (Visiting)
Eric Chun Hei Ho, Ph.D.
Postbaccalaureate Fellow (CRTA)
Rong Qiu
Research Biologist
Robert Sarnovsky

News

Learn more about CCR research advances, new discoveries and more on our news section.