David E. Kleiner, M.D., Ph.D.

David E. Kleiner, M.D., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Laboratory of Pathology


Dr. Kleiner is responsible for overseeing the clinical service component of the Laboratory of Pathology. The laboratory serves as the anatomic pathology service for the NIH Clinical Center, supplying surgical pathology, hepatopathology, autopsy, cytopathology, flow cytometry, ultrastructural pathology, and cytogenetic diagnostic services. These services include both routine diagnostic services and pathology support for the many clinical research protocols carried out at the NIH.

Areas of Expertise

Anatomic Pathology


Selected Publications

Clinical and histological determinants of nonalcoholic steatohepatitis and advanced fibrosis in elderly patients

Noureddin M, Yates KP, Vaughn IA, Neuschwander-Tetri BA, Sanyal AJ, McCullough A, Merriman R, Hameed B, Doo E, Kleiner DE, Behling C, Loomba R.
Hepatology. 2013. [ Journal Article ]

Liver stiffness increases acutely during sickle cell vaso-occlusive crisis

Koh C, Turner T, Zhao X, Minniti CP, Feld JJ, Simpson J, Demino M, Conrey AK, Jackson MJ, Seamon C, Kleiner DE, Kato GJ, Heller T.
Am. J. Hematol.. 2013. [ Journal Article ]

Modeling pathogenesis of primary liver cancer in lineage-specific mouse cell types

Holczbauer A, Factor VM, Andersen JB, Marquardt JU, Kleiner DE, Raggi C, Kitade M, Seo D, Akita H, Durkin ME, Thorgeirsson SS.
Gastroenterology. 145: 221-31, 2013. [ Journal Article ]

Association of IL28B genotype with fibrosis progression and clinical outcomes in patients with chronic hepatitis C: A longitudinal analysis

Noureddin M, Wright EC, Alter H, Clark S, Thomas E, Chen R, Zhao X, Conry-Cantilena C, Kleiner D, Liang TJ, Ghany MG.
Hepatology. 2013. [ Journal Article ]

Case series: biliary leak after transjugular liver biopsy

Fricker Z, Levy E, Kleiner D, Taylor JG, Koh C, Holland SM, Heller T.
Am. J. Gastroenterol.. 108: 145-7, 2013. [ Journal Article ]


Information Technology Specialist
Earle Barnes
Autopsy Assistant
Willie Young