The Thomas lab works at the interface of chemistry and biology mixing pharmacology, chemical biology, medicinal chemistry, systems biology and drug development to explore new translational opportunities across a range of disease states. Scientists in our laboratory use state-of-the-art technologies to conduct large chemogenomic screens of approved and investigational drugs in single agent and combination format as a means to define drug response signatures in multiple disease models. The outcomes of these studies span from basic to translation research.  In the domain of basic research, the outcomes of these studies reveal new insights in pharmacology-informed systems biology. On the translational front, the outcomes of these studies can define new therapeutic opportunities for clinical development. Our medicinal chemistry and drug discovery efforts employ a mix of structure-based and high-throughput methods to identify chemical leads which are then optimized into biologically active probes of key cellular targets. These new, biologically active probes provide important tools that interrogate the functional consequences (phenotypes) associated with inhibiting/activating the targets of interest in key disease models. These tools are offered freely. Occasionally, agents that result from these efforts qualify as investigational drugs and enter human evaluation.