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Photo of Christopher A. Febres-Aldana, M.D.

Christopher A. Febres-Aldana, M.D.

  • Center for Cancer Research
  • National Cancer Institute
Assistant Research Physician
Laboratory of Pathology
Surgical and Molecular Pathologist

RESEARCH SUMMARY

Dr. Febres-Aldana is a surgical and molecular pathologist with expertise in thoracic malignancies, including lung cancer, mesothelioma, thymomas, and interstitial lung diseases (ILD). He practices general surgical pathology to support intramural protocols at NCI and has a nationwide and international referral surgical pathology consult in collaboration with Dr. Markku Miettinen. By implementing multi-omic molecular diagnostic techniques, Dr. Febres-Aldana works on high-quality morpho-molecular correlations for tumor classification and biomarker detection for precision oncology. He also collaborates with scientists across multiple NIH institutes, including groups specialized in non-neoplastic lung diseases at the NHLBI.

Areas of Expertise

Diagnostics and Biomarkers
Cancer Genomics
Mesothelioma
Rare Tumors
Interstitial Lung Diseases

Publications

Selected Recent Publications

Pan-cancer analysis of oncogenic MET fusions reveals distinct pathogenomic subsets with differential sensitivity to MET-targeted therapy

Febres-Aldana CA, Vojnic M, Odintsov I, Zhang T, Cheng R, Beach CZ, Lu D, Mattar MS, Gazzo AM, Gili L, Harshan M, Ameri A, Machnicki S, Xiao X, Lockwood WW, Zhou XY, Yao Q, Drilon A, Rekhtman N, Shah N, Li A, Liu Z, Yang SR, Davare MA, Ladanyi M, Somwar R.
Cancer Discovery. 2025.
Full-Text Article
[ Journal Article ]

Chromothripsis-mediated small cell lung carcinoma

Rekhtman N, Tischfield SE, Febres-Aldana CA* (co-first author), Lee JJ, Chang JC, Herzberg BO, Selenica P, Woo HJ, Vanderbilt CM, Yang SR, Xu F, Bowman AS, da Silva EM, Noronha AM, Mandelker DL, Mehine M, Mukherjee S, Blanco-Heredia J, Orgera JJ, Nanjangud GJ, Baine MK, Aly RG, Sauter JL, Travis WD, Savari O, Moreira AL, Falcon CJ, Bodd FM, Wilson CE, Sienty JV, Manoj P, Sridhar H, Wang L, Choudhury NJ, Offin M, Yu HA, Quintanal-Villalonga A, Berger MF, Ladanyi M, Donoghue MTA, Reis-Filho JS, Rudin CM
Cancer Discovery. 15/1: 83-104, 2025.
Full-Text Article
[ Journal Article ]

Analysis of ASCL1/NEUROD1/POU2F3/YAP1 yields novel insights for the diagnosis of olfactory neuroblastoma and identifies sinonasal tuft cell-like carcinoma

Febres-Aldana CA, Elsayad MM, Saliba M, Bhanot U, Ntiamoah P, Takeyama A, Purgina BM, Rodriguez-Urrego PA, Marusic Z, Jakovcevic A, Chute DJ, Dunn LA, Ganly I, Cohen MA, Pfister DG, Ghossein RA, Baine MK, Rekhtman N, Dogan S
Modern Pathology. 38/3: 100674, 2025.
Full-Text Article
[ Journal Article ]

Cellular ATP demand creates metabolically distinct subpopulations of mitochondria

Ryu KW, Fung TS, Baker DC, Saoi M, Park J, Febres-Aldana CA, Aly RG, Cui R, Sharma A, Fu Y, Jones OL, Cai X, Pasolli HA, Cross J, Rudin CM, Thompson CB
Nature. 635(8039): 746-754, 2024.
Full-Text Article
[ Journal Article ]

HER2 antibody-drug conjugates are active against desmoplastic small round cell tumor

Zhang T, Febres-Aldana CA* (co-first author), Liu Z, Dix JM, Cheng R, Dematteo RG, Lui AJW2, Khodos I, Gili L, Mattar MS, Lisanti J, Kwong C, Linkov I, Tipping MJ, de Stanchina E, Odintsov I, Ladanyi M, Somwar R
Clinical Cancer Research. 30(20): 4701-4713, 2024.
Full-Text Article
[ Journal Article ]