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Christophe E. Redon, Ph.D.

Christophe E. Redon, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute

RESEARCH SUMMARY

Dr. Redon obtained his PhD from the Biochemistry and Cellular Biology Department at the University of Reims Champagne Ardenne, France. His thesis was a study of grape histones. In 1999, Dr. Redon joined Dr. Bonner’s laboratory in the Laboratory of Molecular Pharmacology, CCR, NCI as a Visiting Fellow where he contributed to studies related to DNA damage repair, genomic instability, radiation biology, cancer and drug development among others. As a fellow, Dr. Redon was one of the most dependable, resourceful and diligent researchers in the Bonner laboratory. When his fellowship was completed, Dr. Bonner appointed Dr. Redon as a Staff Scientist in 2010 to lead efforts to develop gamma-H2AX into a clinically useful assay. The gamma-H2AX assay measures DNA damage, in particular the double-strand break (DSB), a lesion central to the therapeutic effects of ionizing radiation and many chemotherapeutic agents. This project places Dr. Redon at a critical intersection of basic research and clinical studies. He is currently involved in several clinical studies related to radiation biodosimetry and cancer drug development. With more than 15 years of laboratory experience, he has co-authored 60 research papers, reviews, and book chapters. He has collaborated with research teams in throughout the world as well as in CCR. Dr. Redon was Recipient of the 2007 NCI Director Innovation Award and three Federal Technology Transfer Awards. He also serves as a mentor for summer students, PhD candidates, and postdoctoral fellows.

Areas of Expertise

clinical, radiation biodosimetry, cancer drug

Publications

Selected Publications

Mito-tempol and dexrazoxane exhibit cardioprotective and chemotherapeutic effects through specific protein oxidation and autophagy in a syngeneic breast tumor preclinical model

Dickey JS, Gonzalez Y, Aryal B, Mog S, Nakamura AJ, Redon CE, Baxa U, Rosen E, Cheng G, Zielonka J, Parekh P, Mason KP, Joseph J, Kalyanaraman B, Bonner W, Herman E, Shacter E, Rao VA.
PLoS ONE. 8: e70575, 2013. [ Journal Article ]

NADPH Oxidases NOXs and DUOXs as putative targets for cancer therapy

Weyemi U, Redon CE, Parekh PR, Dupuy C, Bonner WM.
Anticancer Agents Med Chem. 13: 502-14, 2013. [ Journal Article ]

Oxidative DNA damage caused by inflammation may link to stress-induced non-targeted effects

Sprung CN, Ivashkevich A, Forrester HB, Redon CE, Georgakilas A, Martin OA.
Cancer Lett.. 2013. [ Journal Article ]

Evaluation of the gamma-H2AX assay for radiation biodosimetry in a swine model

Moroni M, Maeda D, Whitnall MH, Bonner WM, Redon CE.
Int J Mol Sci. 14: 14119-35, 2013. [ Journal Article ]