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Chengkai Dai, Ph.D.

Chengkai Dai, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Mouse Cancer Genetics Program

RESEARCH SUMMARY

Dr. Dai's laboratory is a pioneer in the field of proteomic instability of cancer. The recent findings from his laboratory have revealed the intimate interactions between the proteotoxic stress response and RAS/MAPK-MEK signaling, cell cycle regulation, protein translation, as well as tumor-suppressive amyloidogenesis. His ongoing research focuses on the molecular mechanisms through which proteomic instability may affect genomic stability, cell invasion, and autophagy, areas which hold promise to unveil new molecular pathways that could be targeted in cancer
therapy.

Dr. Dai is a 2015-2016 NIH Stadtman tenure track investigator.

Areas of Expertise

1) proteomic instability of cancer 2) the proteotoxic stress response 3) genetically engineered mouse models (GEMM) of cancer

Publications

Selected Key Publications

HSF1 physically neutralizes amyloid oligomers to empower overgrowth and bestow neuroprotection.

Tang Z, Su KH, Xu M, and Dai C.
Science Advances. In Press: 2020. [ Journal Article ]

Heat Shock Factor 1 Is a Direct Antagonist of AMP-Activated Protein Kinase

Su KH, Dai S, Tang Z, Xu M, Dai C
Mol Cell. 76(4): 546-61, 2019. [ Journal Article ]

HSF1 critically attunes proteotoxic-stress sensing by mTORC1 to combat stress and promote growth

Su K-H, Cao J, Dai S, Tang Z, He Y, Sampson SB, Benjamin IV, and Dai C.
Nature Cell Biology. 18(5): 527-539, 2016. [ Journal Article ]

MEK guards proteome stability and inhibits tumor-suppressive amyloidogenesis via HSF1

Tang Z, Dai S, He Y, Doty RA, Shultz LD, Sampson SB, and Dai C.
Cell. 160(4): 729-744, 2015. [ Journal Article ]

Suppression of the HSF1-mediated proteotoxic stress response by the metabolic stress sensor AMPK

Dai S, Tang Z, Cao J, Zhou W, Li H, Sampson S, and Dai C.
EMBO Journal. 34(3): 275-293, 2015. [ Journal Article ]

Job Vacancies

Position Degree Required Contact Name Contact Email
Post-doctoral Fellow - Proteomic instability, HSF1, cancer Ph.D. or equivalent Chengkai Dai, Ph.D. chengkai.dai@nih.gov

Team

Postdoctoral Fellow (Visiting)
Babul Moni Ram, Ph.D.
Research Fellow
Ling Lin, Ph.D.
Visiting Fellow
Omprakash Shriwas, Ph.D.