Caroline Jochems Frohlich, M.D., Ph.D.

Caroline Jochems Frohlich, M.D., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Center for Immuno-Oncology


Dr. Jochems Frohlich's group is involved in studies to identify and modify tumor-associated antigens to enhance their immunogenicity in cancer patients in vaccine-mediated immunotherapy. The group is also involved in studies of HPV-associated malignancies and the use of HPV-directed vaccines in combination with immune modifiers.

Areas of Expertise

Cancer Immunotherapy
Clinical Trials
Tumor Immunology
Cellular Immunology
Immune Biomarkers


Selected Key Publications

Characterization of a recombinant gorilla-adenovirus HPV therapeutic vaccine (PRGN-2009)

Pellom ST, Smalley Rumfield C, Morillon II YM, Roller N, Poppe LK, Brough DE, Sabzevari H, Schlom J, Jochems C.
JCI Insight. 6(7): 141912, 2021.
Full-Text Article
[ Journal Article ]

Immunomodulation to enhance the efficacy of an HPV therapeutic vaccine

Smalley Rumfield C, Pellom ST, Morillon II YM, Schlom J, Jochems C.
J Immunother Cancer. 8(1): e000612, 2020.
Full-Text Article
[ Journal Article ]

ADCC employing an NK cell line (haNK) expressing the high affinity CD16 allele with avelumab, an anti-PD-L1 antibody

Jochems C, Hodge JW, Fantini M, Tsang KY, Vandeveer AJ, Gulley JL, Schlom J.
Int J Cancer. 141(3): 583-593, 2017.
Full-Text Article
[ Journal Article ]

Analyses of functions of an anti-PD-L1/TGFβR2 bispecific fusion protein (M7824)

Jochems C, Tritsch SR, Pellom ST, Su Z, Soon-Shiong P, Wong HC, Gulley JL, Schlom J.
Oncotarget. 8(43): 75217-75231, 2017.
Full-Text Article
[ Journal Article ]

The multi-functionality of N-809, a novel fusion protein encompassing anti-PD-L1 and the IL-15 superagonist fusion complex

Jochems C, Tritsch SR, Knudson KM, Gameiro SR, Rumfield CS, Pellom ST, Morillon YM, Newman R, Marcus W, Szeto C, Rabizadeh S, Wong HC, Soon-Shiong P, Schlom J.
OncoImmunology. 8(2): e1532764, 2018.
Full-Text Article
[ Journal Article ]


Lisa K. Poppe, PhD
Postdoctoral Fellow (CRTA)
Lisa K Poppe, PhD
Nicholas Roller
Nicholas T Roller