Breadcrumb

Caroline Jochems Frohlich, M.D., Ph.D.

Caroline Jochems Frohlich, M.D., Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Center for Immuno-Oncology

RESEARCH SUMMARY

Dr. Jochems Frohlich's group is involved in studies to identify and modify tumor-associated antigens to enhance their immunogenicity in cancer patients in vaccine-mediated immunotherapy. The group is also involved in studies of HPV-associated malignancies and the use of HPV-directed vaccines in combination with immune modifiers.

Areas of Expertise

1) cancer immunotherapy, 2) clinical trials, 3) tumor immunology, 4) cellular immunology, 5) immune biomarkers

Publications

Selected Key Publications

Characterization of a recombinant gorilla-adenovirus HPV therapeutic vaccine (PRGN-2009)

Pellom ST, Smalley Rumfield C, Morillon II YM, Roller N, Poppe LK, Brough DE, Sabzevari H, Schlom J, Jochems C.
JCI Insight. 6(7): 141912, 2021.
Full-Text Article
[ Journal Article ]

Immunomodulation to enhance the efficacy of an HPV therapeutic vaccine

Smalley Rumfield C, Pellom ST, Morillon II YM, Schlom J, Jochems C.
J Immunother Cancer. 8(1): e000612, 2020.
Full-Text Article
[ Journal Article ]

ADCC employing an NK cell line (haNK) expressing the high affinity CD16 allele with avelumab, an anti-PD-L1 antibody

Jochems C, Hodge JW, Fantini M, Tsang KY, Vandeveer AJ, Gulley JL, Schlom J.
Int J Cancer. 141(3): 583-593, 2017.
Full-Text Article
[ Journal Article ]

Analyses of functions of an anti-PD-L1/TGFβR2 bispecific fusion protein (M7824)

Jochems C, Tritsch SR, Pellom ST, Su Z, Soon-Shiong P, Wong HC, Gulley JL, Schlom J.
Oncotarget. 8(43): 75217-75231, 2017.
Full-Text Article
[ Journal Article ]

The multi-functionality of N-809, a novel fusion protein encompassing anti-PD-L1 and the IL-15 superagonist fusion complex

Jochems C, Tritsch SR, Knudson KM, Gameiro SR, Rumfield CS, Pellom ST, Morillon YM, Newman R, Marcus W, Szeto C, Rabizadeh S, Wong HC, Soon-Shiong P, Schlom J.
OncoImmunology. 8(2): e1532764, 2018.
Full-Text Article
[ Journal Article ]

Team

Lisa K. Poppe, PhD
Postdoctoral Fellow (CRTA)
Lisa K Poppe, PhD
Nicholas Roller
Biologist
Nicholas T Roller