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Brice Wilson photo

Brice Wilson, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Associate Scientist
Molecular Targets Program
Head, Assay Development and Screening Section

RESEARCH SUMMARY

The Assay Development and Screening Section (ADSS) develops, optimizes, and implements high throughput screening campaigns for the discovery of biologically active agents for the study and potential treatment of cancer. These campaigns involve close collaboration with CCR Principal Investigators who have targets of interest which may prove tractable for pharmacologic intervention. These purpose-built assays are then used to screen hundreds of thousands of natural products extracts as well as pure compounds for the identification of active agents. Working closely with both CCR investigators and other MTP section, single active entities are isolated, structurally elucidated, and further characterized for activity. ADSS has tremendous expertise in both cell based and biochemical high throughput assay development.

Publications

Selected Publications

Chemical Evolution of Aplithianine Class of Serine/Threonine Kinase Inhibitors

Du, L., Wilson, B. A. P., Moore, W. J., Dalilian, M., Shenoy, S. R., Li, N., Martinez-Fiesco, J. A., Hwang, J-Y., Smith, E. A., Wamiru, A., Goncharova, E. I., Alvarez de la Cruz, A., Pagadala, K., Piswa, H. K., Patteti, V., Jampana, V. P., Manepalli, P., Nimmala, R., Marri, N. R., Gunuguntla, M., Reddy, J. J., Schneekloth Jr., J. S., Zhang, P., O’Keefe, B. R.
Journal of Medicinal Chemistry. Vol 68/Issue 12: 12756–12785, 2025.
Full-Text Article
[ Journal Article ]

Biochemical and biophysical characterization of inositol-tetrakisphosphate 1-kinase inhibitor

Ng, M. Y., Wang, H., Zhang, H., Prucker, I., Perera, L., Goncharova, E., Wamiru, A., Jessen, H. J., Stanley, R. E., Shears, S. B., Luo, J., O'Keefe, B. R., Wilson, B. A. P.
Journal of Biological Chemistry. Vol 301/Issue 3: 108274, 2025.
Full-Text Article
[ Journal Article ]

Furanoheliangolides from Centratherum punctatum and a General Approach for Stereochemical Assignment of Flexible Chiral Side Chains

Khong, Q. T., Marron, L., Huang, S-Y. N., Dalilian, M., Saha, S., Goncharova, E. I., Woldemichael, G. M., Pommier, Y., O’Keefe, B. R., Wilson, B. A. P., Du, L.
Journal of Natural Products. Vol 88/Issue 6: 1413 - 1424, 2025.
Full-Text Article
[ Journal Article ]

Discovery and Synthesis of a Naturally Derived Protein Kinase Inhibitor that Selectively Inhibits Distinct Classes of Serine/Threonine Kinases

Du L, Wilson BAP, Li N, Shah R, Dalilian M, Wang D, Smith EA, Wamiru A, Goncharova EI, Zhang P, O'Keefe BR
J Nat Prod. 86: 2283-2293, 2023. [ Journal Article ]

Biochemical Discovery, Intracellular Evaluation, and Crystallographic Characterization of Synthetic and Natural Product Adenosine 3',5'-Cyclic Monophosphate-Dependent Protein Kinase A (PKA) Inhibitors.

Wilson BAP, Li N, Martinez Fiesco JA, Dalilian M, Wang D, Smith EA, Wamiru A, Shah R, Goncharova EI, Beutler JA, Grkovic T, Zhang P, O'Keefe BR
ACS Pharmacol Transl Sci. . 21: 633-650, 2024. [ Journal Article ]

Team

Anam smiles in a blue shirt and black glasses
Postdoctoral Researcher
Anam Shaikh, Ph.D.