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Brice Wilson photo

Brice Wilson, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Staff Scientist
Molecular Targets Program
Section Head, Assay Development and Screening Section

RESEARCH SUMMARY

The Assay Development and Screening Section (ADSS) develops, optimizes, and implements high throughput screening campaigns for the discovery of biologically active agents for the study and potential treatment of cancer. These campaigns involve close collaboration with CCR Principal Investigators who have targets of interest which may prove tractable for pharmacologic intervention. These purpose-built assays are then used to screen hundreds of thousands of natural products extracts as well as pure compounds for the identification of active agents. Working closely with both CCR investigators and other MTP section, single active entities are isolated, structurally elucidated, and further characterized for activity. ADSS has tremendous expertise in both cell based and biochemical high throughput assay development.

Publications

Selected Publications

Biochemical Discovery, Intracellular Evaluation, and Crystallographic Characterization of Synthetic and Natural Product Adenosine 3',5'-Cyclic Monophosphate-Dependent Protein Kinase A (PKA) Inhibitors.

Wilson BAP, Li N, Martinez Fiesco JA, Dalilian M, Wang D, Smith EA, Wamiru A, Shah R, Goncharova EI, Beutler JA, Grkovic T, Zhang P, O'Keefe BR
ACS Pharmacol Transl Sci. . 21: 633-650, 2024. [ Journal Article ]

Creating and screening natural product libraries

Wilson BAP, Thornburg CC, Henrich CJ, Grkovic T, O'Keefe BR
Nat Prod Rep. 37: 893-918, 2020. [ Journal Article ]

In Vitro Ubiquitination Platform Identifies Methyl Ellipticiniums as Ubiquitin Ligase Inhibitors

Wilson BAP, Voeller D, Smith EA, Wamiru A, Goncharova EI, Liu G, Lipkowitz S, O'Keefe BR.
SLAS Discovery. 26: 8870-884, 2021. [ Journal Article ]

Recifin A, Initial Example of the Tyr-Lock Peptide Structural Family, Is a Selective Allosteric Inhibitor of Tyrosyl-DNA Phosphodiesterase I

Krumpe LRH, Wilson BAP, Marchand C, Sunassee SN, Bermingham A, Wang W, Price E, Guszczynski T, Kelley JA, Gustafson KR, Pommier Y, Rosengren KJ, Schroeder CI, O'Keefe BR
J Am Chem Soc. 142: 21178-21188, 2020. [ Journal Article ]

Discovery and Synthesis of a Naturally Derived Protein Kinase Inhibitor that Selectively Inhibits Distinct Classes of Serine/Threonine Kinases

Du L, Wilson BAP, Li N, Shah R, Dalilian M, Wang D, Smith EA, Wamiru A, Goncharova EI, Zhang P, O'Keefe BR
J Nat Prod. 86: 2283-2293, 2023. [ Journal Article ]