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Ashish Lal, Ph.D.

Ashish Lal, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Genetics Branch

RESEARCH SUMMARY

The human genome is transcribed into thousands of noncoding RNAs. Among the several types of noncoding RNAs, microRNAs and more recently, long noncoding (lncRNAs) have been shown to regulate vital cellular processes, including but not limited to, proliferation, survival and metastasis. Dr. Lal is an expert on noncoding RNAs and cancer. His group has extensively studied small and long non-coding RNAs in p53-mediated tumor suppression and in the regulation of differentiation in colorectal cancer. His lab is also investigating the role of RNA-binding proteins in the regulation of these processes.

Areas of Expertise

lncRNA
MicroRNA
Regulatory RNAs
p53
Differentiation

Publications

Selected Recent Publications

The p53-induced RNA-binding protein ZMAT3 is a splicing regulator that inhibits the splicing of oncogenic CD44 variants in colorectal carcinoma

Muys BR, Anastasakis DG, Claypool D, Pongor L, Li XL, Grammatikakis I, Liu M, Wang X, Prasanth KV, Aladjem MI, Lal A, Hafner M.
Genes Dev. doi: 10.1101/gad.342634.120. Online ahead of print.: 2020. [ Journal Article ]

A small protein encoded by a putative lncRNA regulates apoptosis and tumorigenicity in human colorectal cancer cells.

Li XL, Pongor L, Tang W, Das S, Muys BR, Jones MF, Lazar SB, Dangelmaier EA, Hartford CC, Grammatikakis I, Hao Q, Sun Q, Schetter A, Martindale JL, Tang B, Jenkins LM, Robles AI, Walker RL, Ambs S, Chari R, Shabalina SA, Gorospe M, Hussain PS, Harris CC, Meltzer PS, Prasanth KV, Aladjem MI, Andresson T, Lal A.
eLife. Oct 28;9:e53734. doi: 10.7554/eLife.53734: 2020. [ Journal Article ]

Long noncoding RNA PURPL suppresses basal p53 levels and promotes tumorigenicity in colorectal cancer

Li, X, Subramanian M, Jones MF, Chaudhary R, Singh DK, Zong X, Gryder B, Sindri S, Mo M, Schetter A, Wen X, Parvathaneni S, Kazandjian D, Jenkins LM, Tang W, Elloumi F, Martindale JL, Huarte M, Zhu Y, Robles AI, Frier SM, Rigo F, Cam M, Ambs S, Sharma S, Harris CC, Dasso M, Prasanth KV, Lal A.
Cell Reports. 20(10): 2408-2423, 2017. [ Journal Article ]

Prosurvival long noncoding RNA PINCR regulates a subset of p53 targets in human colorectal cancer cells by binding to Matrin 3

Chaudhary R, Gryder B, Woods WS, Subramanian M, Jones MF, Li X, Jenkins LM, Shabalina SA, Mo M, Dasso M, Yang Y, Wakefield LM, Zhu Y, Frier SM, Moriarity B, Prasanth KV, Perez-Pinera P, Lal A.
eLife. 6 : e23244, 2017. [ Journal Article ]

The CDX1-microRNA-215 axis regulates colorectal cancer stem cell differentiation

Jones MF, Hara T, Francis P, Li XL, Bilke S, Zhu Y, Pineda M, Subramanian M, Bodmer WF, Lal A.
Proc Natl Acad Sci U S A. 112(13): E1550-8, 2015. [ Journal Article ]

Job Vacancies

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Team

Staff Scientist
Yannis Grammatikakis, Ph.D.
Research Biologist
Xiao Ling Li, M.D., Ph.D.
Guest Researcher
Xing Lu
Research Fellow
Bruna Rodrigues Muys, Ph.D.
Postbaccalaureate Fellow (CRTA)
Katherine R. Pasterczyk, B.A.
Postdoctoral Fellow (Visiting)
Ravi Kumar, Ph.D.
Program Support Specialist
Kristen Martin
Collaborator
Sudha Shama
Postbaccalaureate Fellow
Ahlina Archibald
Postdoctoral Fellow (Visiting)
Ragini Singh, Ph. D.

News

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