Annie Gilbert, Ph.D.
- Center for Cancer Research
- National Cancer Institute
- Building 41, Room B1300
- Bethesda, MD 20892
- 240-858-7745
- annie.gilbert@nih.gov
Postdoctoral Fellow
RESEARCH SUMMARY
CENP-A is a centromeric histone H3 variant that serves a critical role in connecting spindle microtubules to centromeres to accurately segregate chromosomes in mitosis. CENP-A is overexpressed in several cancers, and this excess CENP-A is deposited ectopically at fragile chromosomal sites. Previous work shows that H3.3 chaperones and oncogenic lncRNAs mediate mislocalization of CENP-A, and these components serve as exciting therapeutic targets to prevent chromosome fragility. In this work, we are using small molecules to target lncRNA-chaperone complexes to disrupt ectopic deposition of CENP-A and further investigate the mechanism of this CENP-A mislocalization pathway.
Areas of Expertise
Chemical Tool Development
Small Molecule Synthesis