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AR

Anna V. Roschke, Ph.D.

  • Center for Cancer Research
  • National Cancer Institute
Genetics Branch

RESEARCH SUMMARY

Dr. Roschke main research focus is elucidation of mechanisms of chromosomal instability in cancer. Her work on interrogation of the NCI drug discovery panel for drugs and chemical compounds targeting chromosomally unstable cells resulted in identification of specific groups of chemical compounds with elevated cytotoxic activity toward more karyotypically rearranged and/or chromosomally unstable cancer cells.

She has extensive expertise in cancer molecular cytogenetics and provides technical help and training for  fluorescent microscopy techniques: human and mouse spectral karyotyping (SKY), FISH with interphase nuclei and metaphase chromosomes.

Areas of Expertise

Cancer cytogenetics, cancer evolution, chromosomal instability

Publications

Selected Publications

Promiscuous rearrangements of the MYC locus hijack enhancers and super-enhancers to dysregulate MYC expression in multiple myeloma

Affer M, Chesi M, Chen WD, Keats JJ, Demchenko YN, Roschke AV, Van Wier S, Fonseca R, Bergsagel PL, Kuehl WM.
Leukemia. 2014. [ Journal Article ]

Complex IGH rearrangements in multiple myeloma: Frequent detection discrepancies among three different probe sets

Kim GY, Gabrea A, Demchenko YN, Bergsagel L, Roschke AV, Kuehl WM.
Genes Chromosomes Cancer. 2014. [ Journal Article ]

Multi-Layered Cancer Chromosomal Instability Phenotype

Roschke AV, Rozenblum E.
Front Oncol. 3: 302, 2013. [ Journal Article ]

Integrated high-resolution array CGH and SKY analysis of homozygous deletions and other genomic alterations present in malignant mesothelioma cell lines

Klorin G, Rozenblum E, Glebov O, Walker RL, Park Y, Meltzer PS, Kirsch IR, Kaye FJ, Roschke AV.
Cancer Genet. 206: 191-205, 2013. [ Journal Article ]

Efficient repair of DNA double-strand breaks in malignant cells with structural instability

Cheng Y, Zhang Z, Keenan B, Roschke AV, Nakahara K, Aplan PD.
Mutat. Res.. 683: 115-22, 2010. [ Journal Article ]