Anna V. Roschke, Ph.D.
- Center for Cancer Research
- National Cancer Institute
- Building 37, Rm 6016
- Bethesda, MD 20892-5105
- 240-760-7409
- roschkea@nih.gov
RESEARCH SUMMARY
Dr. Roschke main research focus is elucidation of mechanisms of chromosomal instability in cancer. Her work on interrogation of the NCI drug discovery panel for drugs and chemical compounds targeting chromosomally unstable cells resulted in identification of specific groups of chemical compounds with elevated cytotoxic activity toward more karyotypically rearranged and/or chromosomally unstable cancer cells.
She has extensive expertise in cancer molecular cytogenetics and provides technical help and training for fluorescent microscopy techniques: human and mouse spectral karyotyping (SKY), FISH with interphase nuclei and metaphase chromosomes.
Areas of Expertise
Cancer cytogenetics, cancer evolution, chromosomal instability
Anna V. Roschke, Ph.D.
Research
Publications
Selected Publications
Promiscuous rearrangements of the MYC locus hijack enhancers and super-enhancers to dysregulate MYC expression in multiple myeloma
Leukemia.
2014.
[ Journal Article ]
Complex IGH rearrangements in multiple myeloma: Frequent detection discrepancies among three different probe sets
Genes Chromosomes Cancer.
2014.
[ Journal Article ]
Multi-Layered Cancer Chromosomal Instability Phenotype
Front Oncol.
3:
302,
2013.
[ Journal Article ]
Integrated high-resolution array CGH and SKY analysis of homozygous deletions and other genomic alterations present in malignant mesothelioma cell lines
Cancer Genet.
206:
191-205,
2013.
[ Journal Article ]
Efficient repair of DNA double-strand breaks in malignant cells with structural instability
Mutat. Res..
683:
115-22,
2010.
[ Journal Article ]