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Allan M. Weissman, M.D.

Allan M. Weissman, M.D.

  • Center for Cancer Research
  • National Cancer Institute
Cancer Innovation Laboratory

RESEARCH SUMMARY

Our lab studies regulated protein post-translational modifications. We’re particularly interested in the ubiquitin-proteasome system as it relates to normal physiology, cancer, infectious diseases, cardiovascular disease, and other disorders.  Research is focused in four major areas: 1) structure-function relationships of ubiquitin-conjugating enzymes (E2s), ubiquitin protein ligases (E3s), and deubiquitinating enzymes (DUBs); 2) the ubiquitin system at the endoplasmic reticulum (ER) including: ER-associated degradation (ERAD), cellular stress responses, regulation of lipid biosynthesis, and regulation of the innate immune response; 3) the ubiquitin system in mitochondrial regulatory processes and removal of damaged proteins; and 4) the role of ubiquitin system in removing bacterial toxins from cells. Our research program utilizes a wide variety of approaches and employs systems that include cancer cell lines, yeast, mice, and human tissue samples.

Areas of Expertise

1) ubiquitin, 2) ubiquitin ligases, 3) ubiquitin-conjugating enzymes, 4) deubiquitinating enzymes, 5) endoplasmic reticulum-associated degradation, 6) mitochondria, 7) unfolded protein response, 8) cell biology of cancer

Publications

Selected Recent Publications

Deubiquitinating enzyme VCIP135 dictates the duration of the botulinum neurotoxin type A intoxication

Tsai YC, Kotiya A, Kiris E, Yang M, Bavari S, Tessarollo L, Oyler GA, Weissman AM
Proc Natl Acad Sci U S A. 114(26): E5158-E5166, 2017. [ Journal Article ]

The Ubiquitin Ligase (E3) Psh1p is required for proper segregation of both Centromeric and Two-Micron Plasmids in Saccharomyces cerevisiae

Metzger MB, Scales JL, Dunklebarger MF, Weissman AM
G3 (Bethesda). 7(11): 3731-3743, 2017. [ Journal Article ]

An ubiquitin-dependent balance between mitofusion turnover and fatty acids desaturation regulates mitochondrial fusion

Cavellini L, Meurisse J, Findinier J, Erpapazoglou Z, Belgareh-Touze N, Weissman AM, Cohen MM
Nat Commun. 8: 15832, 2017. [ Journal Article ]

Insights into Ubiquitination from the Unique Clamp-like binding of the Ring E3 A07 to the E2 UbcH5B

Li S, Liang YH, Mariano J, Metzger MB, Stringer DK, Hristova VA, Li J, Randazzo PA, Tsai YC, Ji X, Weissman AM
J Biol Chem. 290(51): 30225-39, 2015. [ Journal Article ]

A structually unique E2-binding domain activates ubiquitination by the ERAD E2, Ubc7p, through multiple mechanisms

Metzger MB, Liang YH, Das R, Mariano J, Li S, Li J, Kostova Z, Byrd RA, Ji X, Weissman AM
Mol Cell. 50(4) : 516-27, 2013. [ Journal Article ]

Job Vacancies

There are no open positions at this time. Check back again later, or take a look at CCR's Careers page.

Team

Staff Scientist
Yien Che Tsai, Ph.D.
Research Biologist
Jennifer Mariano, M.S.
Research Biologist
Mei Yang, M.D.
Special Volunteer
Claudia I. Meyer, B.S.
Research Collaborator
Kevin Gardner, M.D., Ph.D.
Postbaccalaureate Fellow
Rebecca Stephanie Su, B.S.
Postbaccalaureate Fellow
Catherine Gill, B.S.
Research Scientist
Meredith Metzger, Ph.D