Breadcrumb

Allan M. Weissman, M.D.

Allan M. Weissman, M.D.

  • Center for Cancer Research
  • National Cancer Institute
Cancer Innovation Laboratory

RESEARCH SUMMARY

Our lab studies regulated protein post-translational modifications. We’re particularly interested in the ubiquitin-proteasome system as it relates to normal physiology, cancer, infectious diseases, cardiovascular disease, and other disorders.  Research is focused in four major areas: 1) structure-function relationships of ubiquitin-conjugating enzymes (E2s), ubiquitin protein ligases (E3s), and deubiquitinating enzymes (DUBs); 2) the ubiquitin system at the endoplasmic reticulum (ER) including: ER-associated degradation (ERAD), cellular stress responses, regulation of lipid biosynthesis, and regulation of the innate immune response; 3) the ubiquitin system in mitochondrial regulatory processes and removal of damaged proteins; and 4) the role of ubiquitin system in removing bacterial toxins from cells. Our research program utilizes a wide variety of approaches and employs systems that include cancer cell lines, yeast, mice, and human tissue samples.

Areas of Expertise

Ubiquitin
Ubiquitin Ligases
Ubiquitin-Conjugating Enzymes
Deubiquitinating Enzymes
Endoplasmic Reticulum-Associated Degradation

Publications

Selected Recent Publications

Differential sensitivity of the yeast Lon protease Pim1p to impaired mitochondrial respiration

Metzger MB, Scales JL, Grant GA, Molnar AE, Loncarek J, Weissman AM
Journal of Biological Chemistry. doi: 10.1016/j.jbc.2023.104937: 2023.
Full-Text Article
[ Journal Article ]

Protein expression of the gp78 E3 ligase predicts poor breast cancer outcome based on race

Singhal SK, Byun JS, Yan T, Yancey R, Caban A, Gil Hernandez S, Bufford S, Hewitt SM, Winfield J, Pradhan J, Mustkov V, McDonald JA, Pérez-Stable EJ, Nápoles AM, Vohra N, De Siervi A, Yates C, Davis MB, Yang M, Tsai YC, Weissman AM, Gardner K
JCI Insight. 7/13: 2022.
Full-Text Article

A structurally conserved site in AUP1 binds the E2 enzyme UBE2G2 and is essential for ER-associated degradation

Smith CE, Tsai YC, Liang YH, Khago D, Mariano J, Li J, Tarasov SG, Gergel E, Tsai B, Villaneuva M, Clapp ME, Magidson V, Chari R, Byrd RA, Ji X, Weissman AM
PLos Biology. 19/12: doi: 10.1371/journal.pbio.3001474, 2021.
Full-Text Article
[ Journal Article ]

A protein quality control pathway at the mitochondrial outer membrane.

Metzger MB, Scales JL, Dunklebarger MF, Loncarek J, Weissman AM
eLife. 2/9: doi: 10.7554/eLife.51065, 2020.
Full-Text Article

Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain

Magnussen HM, Ahmed SF, Sibbet GJ, Hristova VA, Nomura K, Hock AK, Archibald LJ, Jamieson AG, Fushman D, Vousden KH, Weissman AM, Huang DT
Nature Communications. 11/1: doi: 10.1038/s41467-020-15783-y, 2020.
Full-Text Article
[ Journal Article ]

Job Vacancies

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Team

Staff Scientist
Yien Che Tsai, Ph.D.
Research Biologist
Jennifer Mariano, M.S.
Research Biologist
Mei Yang, M.D.
Research Collaborator
Kevin Gardner, M.D., Ph.D.